Docosahexaenoic Acid Induces Adipose Differentiation-Related Protein through Activation of Retinoid X Receptor in Human Choriocarcinoma BeWo Cells
スポンサーリンク
概要
- 論文の詳細を見る
Adipose differentiation-related protein (ADRP) is associated with intracellular lipid droplets that accumulate neutral lipids. Here we report that ADRP expression in a human choriocarcinoma cell line, BeWo, is regulated through activation of retinoid X receptor (RXR) and peroxisome proliferator-activated receptor-γ (PPARγ). Incubation with docosahexaenoic acid (DHA) or oleic acid (OA) induced accumulation of triacylglycerol (TG) and ADRP in BeWo cells. DHA-induced ADRP expression was suppressed by RXR-antagonists, PA452 and HX531. However, oleic acid-induced ADRP expression was not blocked by the RXR-antagonists but by a PPARγ-antagonist. Treatment of the cells with RXR-agonists, HX630 and PA024, increased Adrp transcripts, however, they alone did not change the levels of ADRP protein and TG in BeWo cells. Induction of ADRP protein was observed in the presence of a proteasome inhibitor, suggesting that ADRP is degraded under lipid-poor conditions. These results suggest that expression of ADRP is in part regulated by RXR and PPARγ transcription factors, and DHA induces ADRP by acting as an endogenous agonist of RXR.
著者
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YAMAMOTO Matsuo
Department of Periodontology
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Itabe Hiroyuki
Department Of Biological Chemistry School Of Pharmaceutical Sciences Showa University
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Nishimaki-mogami Tomoko
Div. Of Functional Biochemistry And Genomics National Inst. Of Health Sciences
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Kagechika Hiroyuki
School Of Biomedical Science Tokyo Medical And Dental University
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Suzuki Kazushige
Department Of Pediatrics And Child Health Kurume University School Of Medicine
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Takahashi Katsuhiko
Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University
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Nishimaki-Mogami Tomoko
National Institute of Health Sciences
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Kagechika Hiroyuki
School Of Biomedical Science Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental U
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Suzuki Kazushige
Department of Biological Chemistry, Showa University School of Pharmacy
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Yamamoto Matsuo
Department of Periodontology, Showa University School of Dentistry
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