Chronic Neutrophilic Leukemia with Congenital Robertsonian Translocation Successfully Treated with Allogeneic Bone Marrow Transplantation in a Young Man
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概要
- 論文の詳細を見る
We present a 23-year-old man with chronic neutrophilic leukemia (CNL). Physical examination revealed hepatosplenomegaly. Leukocytosis was evident with predominance of mature neutrophils with basophilic granules. Bone marrow aspiration revealed mature myeloid hyperplasia. Congenital Robertsonian translocation [45,XY,der(13;22)(q10;q10), in all of analyzed 20 cells] was detected; however, cytogenetic and molecular studies for 9:22 translocation were negative. He was diagnosed with CNL and hydroxyurea was started to control his symptoms and white blood cell count. He was then successfully treated with allogeneic bone marrow transplantation (BMT). Although the prognosis of CNL was not determined, curative therapy including allogeneic hematopoietic stem cell transplantation should be attempted in young patients with CNL.
著者
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Moriwaki Hisataka
The First Department Of Internal Medicine Gifu University School Of Medicine
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GOTO Hideko
Department of Internal Medicine, Takayama Red Cross Hospital
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Tanabashi Shinobu
Department Of Internal Medicine Takayama Red Cross Hospital
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Tsurumi Hisashi
The First Department of Internal Medicine, Gifu University Graduate School of Medicine
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Hara Takeshi
The First Department of Internal Medicine, Gifu University Graduate School of Medicine
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