GFP ラット腱板断裂モデルを用いた腱移植後早期の再構築（移植腱細胞の有無による比較）

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The purpose of this study was to examine the behavior of the host and graft cells in early remodeling process after tendon implantation to the defect using a green fluorescent protein (GFP) transgenic rat. Sprague Dawley (SD) rats and GFP rats were used in this study. Tendinous defect were made close to the supraspinatus tendon insertion. In group A, Achilles tendons of SD rats were transplanted into the defect of GFP rats. In group B, frozen Achilles tendons of SD rats were transplanted into the defect of GFP rats. At Zero, 3 and 7 days after surgery, sections stained with hematoxylin and eosin were assessed histologically, and localization of GFP positive cells were also evaluated. Frozen Achilles tendons of GFP rats were also assessed. No cells were observed in the frozen Achilles tendons. The graft was surrounded by inflammatory cells at 3days. Signal positive host cells were observed in the peripheral margins in group A at 3 days. There were no GFP cells in the graft substance. At 7 days, acellular areas remained in the core part of the graft in group B. GFP cells in group B were less infiltrated into graft than in group A. Replacement of graft cells by host cells occurred in the early remodeling process after tendon implantation for the defect of rotator cuff. GFP host cell infiltrated the graft in a frozen Achilles tendon later than that in a live Achilles tendon. It is considered that the live graft cells were important for the repair and the remodeling of the graft.
日本肩関節学会の論文

GFP ラット腱板断裂モデルを用いた腱移植後早期の再構築（移植腱細胞の有無による比較）

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