自家腱移植モデルを用いた腱板修復過程における宿主，移植細胞の動態

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The purpose of this study is to examine the behavior of the host and graft cells in early remodeling process after tendon implantation to the defect using green fluorescent protein (GFP) transgenic rat. 20 Sprague Dawley (SD) rats and 20 green fluorescent protein (GFP) transgenic rats were used in this study. Tendinous defect were made close to the supraspinatus tendon insertion. In group A, the Achilles tendons of SD rats were transplanted into the defect of GFP rats. In group B, the Achilles tendons of GFP rats were transplanted into the defect of SD rats. At 0,1,3,7 and 28 days after surgery, sections stained with hematoxylin and eosin were assessed histologically, and localization of GFP positive cells were also evaluated. The graft was surrounded by inflammatory cells at 3 days. At the bone-tendon insertion, fibroblastic cells started to infiltrate histologically and increased in number in 28 days. In Group A, a small number of signal positive host cells were found around both the bursal and articular side of grafted tendon at 1 day. The host cells increased at 7 days. In Group B, signal positive graft cells were found in the graft at 1 day, which decreased over time. Replacement of graft cells by host cells occurred in the early remodeling process. Infiltrated host cells to both the bursal and articular side play an important role in the early remodeling process after tendon implantation for a defect of the rotator cuff.
日本肩関節学会の論文

自家腱移植モデルを用いた腱板修復過程における宿主，移植細胞の動態

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