Myostatin preferentially down-regulates the expression of fast 2x myosin heavy chain in cattle
スポンサーリンク
概要
- 論文の詳細を見る
Myostatin is involved in an inhibitor of muscular growth and differentiation. Myoblasts derived from double-muscled Japanese shorthorn cattle (DM myoblasts) with absence of functional myostatin had higher abilities to proliferate and differentiate than myoblasts derived from normal-muscled cattle (NM myoblasts). In DM myoblasts, mRNA expressions of fetal myosin heavy chain (MyHC) in growth medium and of fast 2a and 2x MyHC in fusion medium were significantly greater than that in NM myoblasts. No significant difference existed in expressions of embryonic and slow MyHC mRNA between DM and NM myoblasts. The expression of MyoD mRNA was suppressed in myoblasts by administration of myostatin. Two cloned DM myoblast strains (DMc) were established. Addition of myostatin for DMc resulted in less myotube formation and suppression of mRNA expression of fast 2x MyHC. These findings suggest that the endogenous myostatin preferentially down-regulates the expression of the fast 2x MyHC and participates in differentiation of myofiber types during early bovine myogenesis.(Edited by Akira IRITANI, M.J.A.)
著者
-
Yamaguchi Takahiro
Laboratory of Functional Morphology, Department of Animal Production Science, Graduate School of Agr
-
WATANABE Kouichi
Laboratory of Functional Morphology, Department of Animal Science, Graduate School of Agricultural S
-
Miyake Masato
Laboratory Of Functional Morphology Department Of Animal Science Graduate School Of Agricultural Sci
-
Hayashi Sin-ichiro
Laboratory Of Functional Morphology Department Of Animal Science Graduate School Of Agricultural Sci
-
Hayashi Shinichiro
Laboratory For Solid State Chemistry Okayama University Of Science
-
Watanabe Kouichi
Department Of Animal Biology Graduate School Of Agricultural Science Tohoku University
-
Aso Hisashi
Laboratory Of Cellular Biology Laboratory Department Of Animal Physiology National Institute Of Anim
-
Ohwada Shyuichi
Laboratories Of Animal Breeding And Animal Morphology
-
HAYASHI Seigo
Laboratory of Functional Morphology, Department of Animal Biology, Graduate School of Agricultural S
-
Yamaguchi Takahiro
Laboratory Of Functional Morphology Department Of Animal Production Science Faculty Of Agriculture T
-
OHWADA Shyuichi
Laboratory of Functional Morphology, Department of Animal Biology, Graduate School of Agricultural Science, Tohoku University
-
HAYASHI Shinichiro
Laboratory of Functional Morphology, Department of Animal Biology, Graduate School of Agricultural Science, Tohoku University
-
YAMAGUCHI Takahiro
Laboratory of Functional Morphology, Department of Animal Biology, Graduate School of Agricultural Science, Tohoku University
-
YAMAGUCHI Takahiro
Laboratory of Animal Monphology, Faculty of Agriculture, Tohoku University
-
HAYASHI Seigo
Laboratory of Functional Morphology, Department of Animal Biology, Graduate School of Agricultural Science, Tohoku University
-
ASO Hisashi
Laboratory of Functional Morphology, Department of Animal Biology, Graduate School of Agricultural Science, Tohoku University
関連論文
- Differentiation of Mammosomatotrophs in Swine Adenohypophysis
- Differential cytokine expression in T cell subsets from bovine peripheral blood
- Differential expression of myostatin and its receptor in the porcine anterior pituitary gland
- Age-related changes in leukocytes and T cell subsets in peripheral blood of Japanese Black cattle
- P-13. Calcification needs the release of ANX II as well as ANX V from chondrocytes(Abstracts of the International Symposium on Recent Advances in Animal Science(IS-RAAS),Joint meeting of 2^ IS-AS and 3^ IS-IFS)
- D-1. The winding road to candidate genes for marbling(Abstracts of the International Symposium on Recent Advances in Animal Science(IS-RAAS),Joint meeting of 2^ IS-AS and 3^ IS-IFS)
- Bovine Myoblast Differentiation
- Differential characteristics of microfold cells on the dome epithelium of porcine ileum
- Separation and Characterization of Superconducting YBa_2Cu_3O_ Powder : Electrical Properties of Condensed Matter
- Myostatin preferentially down-regulates the expression of fast 2x myosin heavy chain in cattle
- A 63 kDa Tumor Necrosis Factor Inhibitor Released from a Human Monocytic Leukemia Cell Line, THP-1
- Effects of conditioned medium of continuously compressed Human Periodontal Ligament Fibroblasts on MC3T3-E1 cells
- A New Screening Method for the Selection of Lactobacillus acidophilus Group Lactic Acid Bacteria with High Adhesion to Human Colonic Mucosa
- Internal Porosity of Cast Titanium Removable Partial Dentures : Influence of Sprue Design on Porosity in Clasps
- A Comparative Morphometrical Analysis of the Amount and Distribution of Fat within Muscles of Japanese Black Cattle, Japanese Shorthorn, and their Crossbred (F_1) Steers
- Gene Expressions of Muscular Dystrophy in Dwarf Chicken
- Effect of Adrenalin and Noradrenalin on Mitotic Index in Sheep Rumen Epithelium
- Muscle type-specific effect of myostatin deficiency on myogenic regulatory factor expression in adult double-muscled Japanese Shorthorn cattle
- Morphological Characteristics of Gastrointestinal Tract of Syrian Hamsters Bred on an Alfalfa-meal-diet
- Circadian Rhythm of the Mitotic Index in the Rumen Epithelium of Sheep
- A Microphotometric Study on the Proliferation Pattern of Muscle Cell Nuclei in Chickens with Hereditary Muscular Dystrophy
- Effect of Combination Therapy with Lactoferrin and Antibiotics against Staphylococcal Mastitis on Drying Cows
- A Phenotype of Mammary Intra-Epithelial Lymphocytes(mIEL)in Cows
- Myostatin down-regulates the IGF-2 expression via ALK-Smad signaling during myogenesis in cattle
- Cytochemical and Biochemical Characterization of Alkaline Phosphatase in Swine Adenohypophysis
- Dynamics of CD3+ T-cell Distribution throughout the Estrous Cycle and Gestation in the Bovine Endometrium
- TELEsarPHONE : Mutual Telexistence Master-Slave Communication System Based on Retroreflective Projection Technology