Development of Tumor-induced Osteomalacia in a Subcutaneous Tumor, Defined by Venous Blood Sampling of Fibroblast Growth Factor-23
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概要
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A 25-year-old man with severe lumbago was referred to our department for further evaluation. Serum phosphate and TmP/GFR levels were decreased. Physical examination revealed an elastic tumor in the instep of the right foot, which the patient reported having since the age of 10 years. He had no symptoms of osteomalacia at that time. Within the recent years, the tumor had grown in size and the patient developed lumbago. To examine the existence of a fibroblast growth factor-23 (FGF-23)-producing tumor, venous blood was collected from four main veins. FGF-23 levels were significantly increased in the right femoral vein, compared with other veins. After the resection of the tumor, the histopathology was consistent with a phosphaturic mesenchymal tumor (mixed connective tissue variant). Taken together, these results indicated that the development of osteomalacia in this patient was associated with the production of FGF-23 in the subcutaneous tumor.
著者
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Yagihashi Norito
Department of Molecular Pathology, Institute of Brain Science, Hirosaki University Graduate School o
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Suda Toshihiro
Department Of Endocrinology And Metabolism Hirosaki University Graduate School Of Medicine
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Fukumoto Seiji
Division Of Nephrology & Endocrinology Department Of Internal Medicine University Of Tokyo Hospi
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Masuda Mitsuo
The First Department Of Internal Medicine Aomori City Hospital
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Kageyama Kazunori
Department Of Endocrinology And Metabolism Hirosaki University Graduate School Of Medicine
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Kikuchi Toru
The First Department Of Internal Medicine Aomori City Hospital
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Ogura Eriko
The First Department of Internal Medicine, Aomori City Hospital
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Fukuda Yoshiko
The First Department of Internal Medicine, Aomori City Hospital
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