Exaggerated Response of Adrenocorticotropic Hormone to Growth Hormone-Releasing Peptide-2 Test in Cushing's Disease : Case Report
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概要
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A 47-year-old woman presented with a pituitary microadenoma manifesting as typical Cushings syndrome. The diagnosis was Cushings disease based on the endocrinological findings. Plasma adrenocorticotropic hormone (ACTH) levels were greatly increased from 66 pg/ml to 2490 pg/ml (about 38-fold) in response to the administration of 100 μg human growth hormone-releasing peptide (GHRP)-2. GHRP receptor type 1a messenger ribonucleic acid was detected in the tumor. Therefore, GHRP-2 may stimulate ACTH via the GHRP receptor type 1a in pituitary ACTH-producing tumor. The GHRP-2 test, currently clinically available in Japan, may be a useful diagnostic tool for Cushings disease.
- 2009-08-15
著者
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Suda T
Department Of Endocrinology And Metabolism Hirosaki University Graduate School Of Medicine
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Suda Toshihiro
Department Of Endocrinology And Metabolism Hirosaki University Graduate School Of Medicine
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Naraoka Maki
Department of Endocrinology and Metabolism, Hirosaki University Graduated School of Medicine
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Kageyama Kazunori
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
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Suda Toshihiro
The Third Department Of Internal Medicine Hirosaki University School Of Medicine
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NIGAWARA TAKESHI
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
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SAKIHARA SATORU
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
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Sakihara Satoru
Department Of Endocrinology And Metabolism Hirosaki University Graduate School Of Medicine
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Naraoka Maki
Department Of Endocrinology And Metabolism Hirosaki University Graduate School Of Medicine
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Ikeda Hidetoshi
Research Institute For Pituitary Diseases Southern Tohoku General Hospital
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MATSUMOTO Atsufumi
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
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TSUSHIMA Yuko
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
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TERUI Ken
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine
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Kageyama Kazunori
Department Of Endocrinology And Metabolism Hirosaki University Graduate School Of Medicine
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Terui Ken
Department Of Endocrinology And Metabolism Hirosaki University Graduate School Of Medicine
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Tsushima Yuko
Department Of Endocrinology And Metabolism Hirosaki University Graduate School Of Medicine
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Matsumoto Atsufumi
Department Of Endocrinology And Metabolism Hirosaki University Graduate School Of Medicine
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Nigawara Takeshi
Department Of Endocrinology And Metabolism Hirosaki University Graduate School Of Medicine
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Kageyama Kazunori
Dep. Of Endocrinology And Metabolism Hirosaki Univ. Graduate School Of Medicine Hirosaki Jpn
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