Effects of Meluadrine Tartrate on Maternal Metabolic Responses and Fetal Hemodynamics in Pregnant Goats
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概要
- 論文の詳細を見る
This study was designed to elucidate the effects of meluadrine tartrate on maternal metabolic responses and fetal hemodynamics in unanesthetized, chronically instrumented pregnant goats. After the administration of meluadrine tartrate to pregnant goats or directly to fetuses, changes in heart rate (HR), arterial blood pressure and arterial blood pH, gasses, electrolytes and metabolic responses were measured. The constant administration of meluadrine tartrate (0.1 μg · kg−1 · min−1) to pregnant goats resulted in the increases of maternal HR, glucose and free fatty acid and the decrease of maternal blood K+ concentration. The direct escalating administration of meluadrine tartrate (0.01, 0.03 and 0.1 μg · kg−1 · min−1) did not increase the fetal HR, while ritodrine hydrochloride (0.3, 1 and 3 μg · kg−1 · min−1) to fetuses increased the fetal HR dose-dependently. The present study suggests that meluadrine tartrate has a mild influence relative to the effects of ritodrine to the maternal metabolic responses and fetal cardiovascular function.
- 社団法人 日本薬理学会の論文
- 2002-10-01
著者
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IKENOUE Tsuyomu
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki
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Sakamoto Hiroshi
Department of Cardiology, The Jikei University School of Medicine
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MATSUDA Yoshio
Department of Obstetrics and Gynecology, Tokyo Womens' Medical University
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Ikenoue Tsuyomu
Perinatology Center Kagoshima Municipal Hospital
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Ikenoue Tsuyomu
Departments Of Obstetrics And Gynecology Miyazaki Medical College
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Kouno Satoshi
Department of Industrial Chemistry, Tokyo University of Agriculture and Technology
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Kouno Satoshi
Department Of Obstetrics And Gynecology Kagoshima City Hospital
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Matsuda Yoshio
Tokyo Women's Medical Univ. Tokyo Jpn
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Matsuda Yoshio
東京女子医科大学 産婦人科学
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Matsuda Yoshio
Department Of Obstetrics And Gynecology Tokyo Women's Medical University
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Ikenoue Tsuyomu
Department Of Obstetrics And Gynecology And Perinatal Center Faculty Of Medicine University Of Miyaz
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Sakamoto H
Department Of Veterinary Medicine Faculty Of Agriculture Kaoshima University
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Sakamoto Hiroshi
Department Of Bioscience And Bioinformatics Graduate School Of Computer Science And Systems Engineer
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Matsuda Yoshio
Department Of Biology Faculty Of Science Osaka City University
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Sakamoto Hiroshi
Department Of Anatomy And Cell Biology Interdisciplinary Graduate School Of Medicine And Engineering
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Sakamoto Hiroshi
Deparment Of Biology Faculty Of Science Kobe University
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Matsuda Yoshio
Department Of Applied Physics Osaka University
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IKENOUE Tsuyomu
Department of Obstetrics & Gynecology, Faculty of Medicine, University of Miyazaki
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