Effects of Meluadrine Tartrate and Ritodrine Hydrochloride on Oxytocin-Induced Uterine Contraction, Uterine Arterial Blood Flow and Maternal Cardiovascular Function in Pregnant Goats
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概要
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This study was designed to elucidate the effects of meluadrine tartrate on oxytocin-induced uterine contraction and maternal hemodynamics in unanesthetized, chronically instrumented pregnant goats. After the administration of meluadrine tartrate or ritodrine hydrochloride to pregnant goats, changes in heart rate (HR), arterial blood pressure (AOP), and arterial blood pH and gasses (PO2 and PCO2) in the mother, as well as changes in intrauterine pressure (IUP) and uterine arterial blood flow (UBF), were measured. The escalating administration of meluadrine tartrate (0.03, 0.1, 0.3 and 1 μg · kg−1 · min−1) or ritodrine hydrochloride (1, 3, 10 and 30 μg · kg−1 · min−1) to the maternal femoral vein caused a marked and similar inhibition in oxytocin-induced uterine contraction (a rise in IUP). By these escalating dosings, maternal HR was increased dose-dependently in both treatment groups; however, the degree of the HR increase in the meluadrine tartrate-treatment group was significantly less than that in the ritodrine hydrochloride-treatment group. Furthermore, the degree of the UBF decrease in the meluadrine tartrate-treatment group was significantly less than that in the ritodrine hydrochloride-treatment group. The present study suggests that meluadrine tartrate has a mild influence on the maternal cardiovascular function relative to the effects of ritodrine taking the potent efficacy on oxytocin-induced uterine contraction into account.
- 社団法人 日本薬理学会の論文
- 2002-10-01
著者
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IKENOUE Tsuyomu
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Miyazaki
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Sakamoto Hiroshi
Department of Cardiology, The Jikei University School of Medicine
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MATSUDA Yoshio
Department of Obstetrics and Gynecology, Tokyo Womens' Medical University
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Ikenoue Tsuyomu
Perinatology Center Kagoshima Municipal Hospital
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Ikenoue Tsuyomu
Departments Of Obstetrics And Gynecology Miyazaki Medical College
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Kouno Satoshi
Department of Industrial Chemistry, Tokyo University of Agriculture and Technology
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Kouno Satoshi
Department Of Obstetrics And Gynecology Kagoshima City Hospital
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Matsuda Yoshio
Tokyo Women's Medical Univ. Tokyo Jpn
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Matsuda Yoshio
東京女子医科大学 産婦人科学
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Matsuda Yoshio
Department Of Obstetrics And Gynecology Tokyo Women's Medical University
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Ikenoue Tsuyomu
Department Of Obstetrics And Gynecology And Perinatal Center Faculty Of Medicine University Of Miyaz
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Sakamoto H
Department Of Veterinary Medicine Faculty Of Agriculture Kaoshima University
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Sakamoto Hiroshi
Department Of Bioscience And Bioinformatics Graduate School Of Computer Science And Systems Engineer
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Matsuda Yoshio
Department Of Biology Faculty Of Science Osaka City University
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Sakamoto Hiroshi
Department Of Anatomy And Cell Biology Interdisciplinary Graduate School Of Medicine And Engineering
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Sakamoto Hiroshi
Deparment Of Biology Faculty Of Science Kobe University
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Matsuda Yoshio
Department Of Applied Physics Osaka University
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IKENOUE Tsuyomu
Department of Obstetrics & Gynecology, Faculty of Medicine, University of Miyazaki
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