The Inhibitory Effects of Aqueous Extract of Magnolia officinalis on Human Mesangial Cell Proliferation by Regulation of Platelet-Derived Growth Factor-BB and Transforming Growth Factor-β1 Expression
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概要
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Mesangial cell (MC) proliferation, mediated by platelet-derived growth factor (PDGF)-BB, transforming growth factor (TGF)-β1, and cyclin-dependent kinases (CDK), is the common feature of glomerulosclerosis. Magnolia officinalis, stem bark of Machilus thunbergii S., has multiple pharmacological effects. In this study, we investigated the influence of aqueous extract of Magnolia officinalis on MC proliferation, DNA synthesis, and expression of PDGF-BB, TGF-β1, CDK1, CDK2, and CDK4 in fetal bovine serum (FBS)-activated human MC. Magnolia officinalis inhibited the MC proliferation, DNA synthesis, and the expression of PDGF-BB, CDK1, and CDK2 gene and CDK1, CDK2, and TGF-β1 protein. These results suggest that the inhibitory effect of Magnolia officinalis on MC proliferation may be mediated by regulation of PDGF-BB and TGF-β1expressions and by modulation of CDK1 and CDK2 expression.
- 社団法人 日本薬理学会の論文
- 2004-01-01
著者
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JIN Sheng-Yu
Department of Pharmacology, College of Medicine, Kohwang Medical Research Institute, Kyung Hee Unive
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Kim Sung-do
韓国
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Kim Sung-do
East West Medical Center Kyung Hee University
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Ahn Se-young
Department Of Internal Medicine College Of Oriental Medicine Kyung Hee University
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Lee B‐c
Biomedical Physics Lab. School Of Physics Seoul National University
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Lee Byung-cheol
Department Of Internal Medicine College Of Oriental Medicine Kyung Hee University
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Jin Sheng-yu
Department Of Pharmacology College Of Medicine Kyung Hee University
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Jin Sheng-yu
Department Of Pharmacology College Of Medicine Kohwang Medical Research Institute Kyung Hee Universi
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LEEM Kang-Hyun
College of Korean Medicine, Semyung University
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Leem Kang-hyun
College Of Oriental Medicine Semyung University
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Leem Kang-hyun
College Of Korean Medicine Semyung University
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DOO Ho-Kyng
Department of Internal Medicine, College of Oriental Medicine Kyung Hee University
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LEE Hee-Jae
Department of Pharmacology, College of medicine Kyung Hee University
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JUNG Joo-Ho
Department of Pharmacology, College of medicine Kyung Hee University
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HONG Seung-Jae
East West Medical Center Kyung Hee University
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LEE Sang-Ho
East West Medical Center Kyung Hee University
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PARK Jae-Kyung
WHO Collaborating Center of Traditional Medicine Kyung Hee University
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Doo Ho-kyung
Department Of Internal Medicine College Of Oriental Medicine Kyung Hee University
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Jung Joo-ho
Department Of Pharmacology College Of Medicine Kyung Hee University
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Lee Hee-jae
Department Of Pharmacology College Of Medicine Kyung Hee University
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