Cyclooxygenase Inhibitors Attenuate Augmented Glutamate Release in Organum Vasculosum Laminae Terminalis and Fever Induced by Staphylococcal Enterotoxin A
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概要
- 論文の詳細を見る
Both the hyperthermia and augmented glutamate release in the organum vasculosum laminae terminalis (OVLT) after an intravenous dose (30 ng/kg) of staphylococcal enterotoxin A (SEA) were significantly reduced by pretreatment with intravenous administration of cyclooxygenase inhibitors such as aspirin (1 – 10 mg/kg), sodium salicylate (1 – 10 mg/kg), or diclofenac (10 mg/kg). Intra-OVLT administration of 50 – 200 μg in 1.0 μl of either aspirin or sodium salicylate 60 min before or 120 min after an intra-OVLT dose (50 μg in 1.0 μl) of glutamate also significantly suppressed the glutamate-induced hyperthermia. These findings suggest that inhibition of cyclooxygenase receptor mechanisms suppresses SEA fever by inhibition of glutamate release in the OVLT of rabbit brain.
- 社団法人 日本薬理学会の論文
- 2004-02-01
著者
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Lin Mao-tsun
台湾
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HUANG Wu-Tein
Department of Health Care Administration, Diwan College of Management
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LIN Mao-Tsun
Department of Medical Research, Chi Mei Medical Center
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WANG Jhi-Joung
Department of Medical Research, Chi-Mei Foundation Hospital
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Wang Jhi-joung
Department Of Anesthesiology Tri-service General Hospital
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Wang Jhi-joung
Department Of Medical Research Chi-mei Foundation Hospital
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Lin M‐t
Department Of Medical Research Chi-mei Medical Center
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Lin Mao-tsun
Departmen T Of Physiology National Yang-ming University
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Huang Wu-tein
Department Of Health Care Administration Diwan College Of Management
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Huang W‐t
Department Of Health Care Administration Di Wan College Of Management
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