Catecholaminergic Mechanisms-Mediated Hypothermia Induced by Magnolol in Rats

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概要

• 論文の詳細を見る

• Intraperitoneal administration of magnolol (25 - 100 mg/kg) produced a dose-related fall in rats’ colonic temperature. The magnolol-induced hypothermia was attenuated by pretreatment with intracerebroventricular 6-hydroxydopamine (200 μg/rat). The L-DOPA (200 mg/kg, i.p.) plus benserazide (50 mg/kg, i.p.)-induced hyperthermia was attenuated by magnolol. On the other hand, the α-methyltyrosine (100 mg/kg, i.p.)-induced hypothermia was potentiated by magnolol. Furthermore, magnolol (50 mg/kg, i.p.) decreased the dopamine and norepinephrine release in the hypothalamus, but did not change the concentrations for their metabolites (3, 4-dihydroxyphenylacetic acid and homovanillic acid). The data suggest that magnolol decreases colonic temperature by reducing catecholaminergic activity in rat hypothalamus.

• 社団法人 日本薬理学会の論文
• 1998-12-01

著者

• Hsieh M‐t

  Graduate Inst. Of Chinese Pharmaceutical Sciences Coll. Of Pharmacy China Medical Univ. Taiwan

• CHEN Chieh-Fu

  National Research Institute of Chinese Medicine

• Lin Mao-tsun

  台湾

• HSIEH Ming-Tsuen

  Institute of Chinese Pharmaceutical Sciences, China Medical College

• LIN Mao-Tsun

  Department of Medical Research, Chi Mei Medical Center

• Chen C‐f

  National Res. Inst. Chinese Medicine Taipei Twn

• Lin M‐t

  Department Of Medical Research Chi-mei Medical Center

• Chueh Fu-yu

  Institute Of Chinese Pharmaceutical Sciences China Medical College

• Lin Mao-tsun

  Departmen T Of Physiology National Yang-ming University

• LIN Shui-mu

  Institute of Chinese Pharmaceutical Sciences, China Medical College

• CHUEH Fu-shin

  Institute of Chinese Pharmaceutical Sciences, China Medical College

• Lin Shui-mu

  Institute Of Chinese Pharmaceutical Sciences China Medical College

• CHEN Chieh-Fu

  National and Research Institute of Chinese Medicine

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