Changes in Blood Viscosity With Synthetic Protease Inhibitors

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概要

• 論文の詳細を見る

• We examined the effects on whole blood viscosity and coagulation time of various dosages of the synthetic low-molecular protease inhibitors gabexate mesilate and nafamostat mesilate with an oscillation-type viscometer. When either agent was added, blood viscosity decreased dose-dependently along a sigmoid-like curve. Furthermore, coagulation time was shorter with gabexate mesilate than with nafamostat mesilate owing to the differences of half-life in human blood. Thrombin generation, which results from the activation of coagulation factors, is inhibited by synthetic protease inhibitors and subsequently decreases blood viscosity dose-dependently.

• 社団法人 日本薬理学会の論文
• 2003-04-01

著者

• HITOSUGI Masahito

  Department of Legal Medicine, Dokkyo University School of Medicine

• TOKUDOME Shogo

  Department of Legal Medicine, Dokkyo University School of Medicine

• Tokudome Shogo

  Department Of Legal Medicine Dokkyo Medical University School Of Medicine

• Tokudome Shogo

  Department Of Legal Medicine School Of Medicine Dokkyo Medical University

• Hitosugi Masahito

  Department Of Forensic Medicine Jikei University School Of Medicine

• Hitosugi M

  Jikei Univ. School Of Medicine Tokyo Jpn

• NAGAI Toshiaki

  Department of Electrical and Electronic Engineering, Tokyo Institute of Technology

• Hitosugi Masahito

  獨協医科大学 医学部法医学

• KUROSU Akira

  Department of Legal Medicine, Dokkyo Medical University, School of Medicine

• Kurosu Akira

  Department Of Legal Medicine Dokkyo Medical University School Of Medicine

• NIWA Munehiro

  Faculty of Policy Informatics, Chiba University of Commerce

• TAKAHASHI Tomoyoshi

  Department of Chemistry, Jikei University School of Medicine

• NIHEI Hirohisa

  Department of Legal Medicine, Dokkyo University School of Medicine

• Nihei Hirohisa

  Department Of Legal Medicine Dokkyo University School Of Medicine

• Nagai Taku

  Department Of Neuropsychopharmacology And Hospital Pharmacy Nagoya University Graduate School Of Med

• Takahashi Tomoyoshi

  Department Of Chemistry Jikei University School Of Medicine

• Niwa Munehiro

  Chiba Univ. Commerce Chiba Jpn

• TOKUDOME Shogo

  Department of Legal Medicine, Dokkyo Medical University School of Medicine

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