New Protocol to Detect Coronary Spastic Angina without Fixed Stenosis.
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概要
- 論文の詳細を見る
A new combined test, accelerated exercise following mild hyperventilation (HV), was examined to determine whether it is effective at detecting a positive response in patients with pharmacologically-induced coronary vasospasm and near normal coronary arteries. Fifty-eight consecutive patients who underwent both triple non-invasive spasm provocation tests and diagnostic coronary angiography were enrolled. They all had pharmacologically-induced coronary vasospasms and no significant organic stenosis. In these patients, an HV test was performed first, followed by a treadmill exercise test (TET), and finally the new combined test under no medication within 3 days. Of the 58 patients, positive responses were observed in 9 patients to the HV, in 15 to the TET, and in 35 to the newly combined test. The remaining 21 patients had negative responses although the triple sequential tests were perfomed. Thus, the sensitivities of the HV test, TET, and newly combined test were 16% (9/58), 26% (15/58), and 63% (35/56), respectively. Forty-six subjects with near normal coronary arteries and no ACh-provoked spasm served as controls. None of these subjects had positive responses to any of these three tests, and thus their specificity was all 100%. No serious or irreversible complications were seen in this study. We recommend this newly-combined protocol for the induction of coronary artery spasm in patients with vasospastic angina pectoris and without significant stenosis as a diagnostic tool.
- International Heart Journal刊行会の論文
著者
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Ochi Naoto
Department of Cardiology, Kita Medical Association Hospital
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Uraoka Tadao
Department of Cardiology, Kita Medical Association Hospital
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Matsuda Shouzou
Department of Cardiology, Kita Medical Association Hospital
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Sueda Shozo
Department Of Cardiology Ehime Prefectural Niihama Hospital
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Ochi Naoto
Department Of Cardiology Kita Medical Association Hospital
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Uraoka Tadao
Department Of Cardiology Kita Medical Association Hospital
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Kawada Hiroyuki
Department Of Cardiology Ehime Prefectural Imabari Hospital
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Hashimoto Haruhisa
Department Of Internal Medicine Yoshida General Hospital
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Hayashi Yutaka
Department Of Cardiology Uwajima Social Insurance Hospital
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Tsuruoka Takashi
Department of Cardiology, Kita Medical Association Hospital
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Hashimoto Haruhisa
Department of Cardiology, Yoshida General Hospital
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Sueda Shozo
Department of Cardiology, Kita Medical Association Hospital
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KAWADA Hiroyuki
Department of Applied Mechanics and Aerospace Engineering, Waseda University
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