Pretreatment of Leishmania Homologue of Receptors for Activated C Kinase (LACK) Promotes Disease Progression Caused by Leishmania amazonensis

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概要

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• A cDNA coding Leishmania homologue of receptors for activated C kinase (LACK), which was known to play an important role in the early phase of Leishmania infection, was molecularly cloned from Leishmania amazonensis promastigote by using reverse transcription and nested polymerase chain reaction, and was sequenced. The L. amazonenis LACK cDNA showed 97.3 to 99.3% homology and its deduced amino acid sequence showed 98.7 to 99.7% identity in comparison with LACK sequences from five other species. The amino acid sequences in the immunodominant peptide region were completely conserved among Leishmania spp. tested. Intravenous pretreatment of the recombinant L. amazonensis LACK into BALB/c mice showed progressive lesion development compared to PBS (−) injected control mice, suggesting the important role of LACK in the early phase of L. amazonensis infection.

• 社団法人　日本実験動物学会の論文
• 2002-07-01

著者

• MATSUMOTO Yasunobu

  Laboratory of Global Animal Resource Science, Graduate School of Agricultural and Life Sciences, The

• Okuno Takahiro

  Laboraatory Of Global Animal Resource University

• MATSUMOTO Yoshitsugu

  Department of Molecular Immunology, Graduate School of Agriculture and Life Sciences, University of

• Matsumoto Yoshitsugu

  Department Of Molecular Immunology School Of Agricultural And Life Sciences University Of Tokyo

• Matsumoto Yoshitsugu

  Department Of Molecular Immunology Graduate School Of Agricultural And Life Sciences The University

• OTSUKA Haruki

  Laboraatory of Global Animal Resource University

• TAKEUCHI Makoto

  Laboratory of Global Animal Resource Science

• Matsumoto Yukio

  Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med

• Matsumoto Yasunobu

  Faculty Of Agriculture The University Of Tokyo

• Matsumoto Yasunobu

  Laboratory Of Global Animal Resource Science Graduate School Of Agricultural And Life Sciences Unive

• Takeuchi Makoto

  Laboratory Of Germfree Life Research Institute For Disease Mechanism And Control Nagoya University S

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