Effects of Hydrophobic and Electrostatic Interactions on Change in Decapeptide Conformation in Micelle and Liposome Solution

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概要

• 論文の詳細を見る

• Examination was made of the title effects in water, methanol and aqueous solutions of micelles and liposomes. Lysine (Lys) scanning decapeptides each containing norleucine (Nle) and alanine (Ala) were synthesized and their conformations determined by circular dichroism (CD). Conformational transition from α-helix to β-structure was noted in nearly every decapeptide. Each decapeptide was examined for its capacity to form amyloids by fluorescence using Thioflavin T. Increase in fluorescence was clear indication of the high capacity of Ala-Nle-Ala-Lys-Ala-Ala-Ala-Ala-Nle-Ala (2-9X4K) to form amyloids. Decapeptide interactions with acidic liposome were assessed based on entrapped 5(6)-carboxyfluorescein (CF) leakage. Leakage capacity of Ala-Nle-Ala-Ala-Ala-Ala-Lys-Ala-Nle-Ala (2-9X7K) was found greater than that of 2-9X4K.

• 日本油化学会の論文
• 2004-12-01

著者

• Akisada H

  Department Of Biological Substances And Life Science Faculty Of Engineering Kyushu Kyoritsu Universi

• Akisada Hideo

  Department Of Biological Substances And Life Science Faculty Of Engineering Kyushu Kyoritsu Universi

• Kato T

  Univ. Tokyo Tokyo

• Kato Tamaki

  Graduate School Of Life Science And Systems Engineering Kyushu Institute Of Technology

• Tomizaki K

  Kyushu Inst. Of Technol. Fukuoka Jpn

• KUWAHARA Junko

  Department of Biological Substances and Life Science, Faculty of Engineering, Kyushu Kyoritsu Univer

• NISHINO Norikazu

  Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology

• Nishino N

  Graduate School Of Life Science And Systems Engineering Kyushu Institute Of Technology

• Nishino Norikazu

  Graduate School Of Life Science And Systems Engineering Kyushu Institute Of Technology

• Kato T

  Graduate School Of Life Science And Systems Engineering Kyushu Institute Of Technology

• Kuwahara Junko

  Department Of Life Environment And Material Science Faculty Of Engineering Fukuoka Institute Of Tech

• Kato Tamaki

  Department Of Biological Functions And Engineering Graduate School Of Life Science And Systems Engin

• Nishino Norikazu

  Department Of Biological Functions And Engineering Graduate School Of Life Science And Systems Engin

• Nishino Norikazu

  Graduate School Of Life Science And Systems Engineering Kyushu Instetute Of Technology

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