High Throughput Screening System for Histone Methyltransferase Inhibitors

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概要

• 論文の詳細を見る
• 2011-03-01

著者

• Yoshida Minoru

  Riken

• Nishino N

  Graduate School Of Life Science And Systems Engineering Kyushu Institute Of Technology

• Nishino Norikazu

  Department Of Biological Functions And Engineering Graduate School Of Life Science And Systems Engin

• Ito Akihiro

  Riken

• Nishino Norikazu

  Graduate School Of Life Science And Systems Engineering Kyushu Instetute Of Technology

• CHI Hongfang

  Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology

• NSIAMA Tienabe

  Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology

• TAKEMOTO Yasushi

  RIKEN

• Chi Hongfang

  Graduate School Of Life Science And Systems Engineering Kyushu Institute Of Technology

• Nsiama Tienabe

  Graduate School Of Life Science And Systems Engineering Kyushu Institute Of Technology

関連論文

• A Menbrane Protein Model : Polypeptides with Four α-Helix Bundle Sturcture on 5,10,15,20-Tetrakis[2-(carboxymethoxy)phenyl]porphyrin
• De Novo Design and Synthesis of Four α-Helix Bundle Proteins with Flavin Function
• 5,10,15,20-Tetrakis(2-amino-6-methoxycarbonylphenyl)porphyrin. Synthesis and Separation of Atropisomers Useful for Porphyrin Architecture
• Dansyl and Indolyl Groups as a Probing Pair for Intersegmental Arrangement in Four- α-Helix Bundle Structure of a Polypeptide
• Efficient Preparation of αβαβ-Atropisomer of meso-Tetra(ο-aminophenyl)porphyrin
• Design of a Hybrid of Two α-Helix Peptides and Ruthenium Trisbipyridine Complex for Photo-induced Electron Transfer System in Bilayer Membrane
• Molecular Assembly of Zinc-Nickel Hybrid Porphyrin Dimer Using Synthetic 4α-Helix Polypeptides
• Molecular Assembly of Bachteriochlorophyll a and Its Analogues by Synthetic 4α-Helix Polypeptides
• Trisbipyridine Metal Ion's Nest in Three α-Helix Bundle Structure
• Alamethicin Oligomers Tethered on Cyclic Pseudopeptides
• Synthesis and Properties of Cyclic Pseudopeptides Containing Dipeptide Isosteres
• Synthesis and Characterization of Peptide-Surfactants Using Elastin Repeating Unit
• Fluorescence Energy Transfer to Tailed Acridine Oranges from Pyrene Excimer in Four α-Helix Bundle 53-peptide
• Construction of Four α-Helix Bundle Structure with L- and D-Amino Acid Segments
• The Building of Antiparallel Four α-Helix Bundle Structure with a Pair of Pyrenylalanines on a Cyclic Pseudo-peptide Template
• Synthesis of Chlamydocin and HC-toxin Hydroxamic Acid Analogs Containing Acyclic Imino Acids and Conformational Effect in Inhibition of Histone Deacetylases
• HC-toxin and Chlamydocin Analogs Bearing Hydroxamic Acid as Histone Deacetylase Inhibitors
• Synthesis and Properties of Cyclic Peptides Arranging a Pair of Porphyrin and Fullerene C_
• Aromatic Ring Shifting in Chlamydocin Framework for Specific Inhibition of Histone Deacetylase Paralogs
• Design and Synthesis of Histone Deacetylase Inhibitors Containing Hydroxy-Imino-Acids as the Capping Group
• 2P585 Toward Potent HDAC Inhibitor Design : Insights from Homology Modeling and Docking Simulation of HDAC and Its Inhibitors(55. Drug design and delivery,Poster Session,Abstract,Meeting Program of EABS &BSJ 2006)
• Design and Synthesis of Histone Deacetylase Inhibitors Containing Trifluoromethylketone Moiety as the Functional Group
• Facile Synthesis of Modified Cyclic Imino Acids with Methyl and Hydroxyl Groups
• Repetitive Interactions Observed in the Crystal Structure of a Collagen-Model Peptide, [(Pro-Pro-Gly)_9]_3
• Advanced Technology for the Production of Monoclonal Antibodies Based on In Vitro Immunization
• Effects of Hydrophobic and Electrostatic Interactions on Change in Decapeptide Conformation in Micelle and Liposome Solution
• Rapid Generation of Monoclonal Antibodies against the Epitope Sequences of Human Insulin Using an In Vitro Immunization Method
• Aniline-Hydroxylation Activity of a Flavin-linked βαβα-Type Polypeptide Packing an Iron Porphyrin
• Complexation of 4,4'-Dipyridyl Derivatives Changed the Orientations of Metalloporphyrins Linked to the Cyclic Peptide Gramicidin S
• An Attempt to Build Electron Transfer System in Dendritic Poly(L-Lysine)
• Analysis of Epitope Sequences Based on B Cell Targeting Technique
• CD Investigation of Porphyrin-Porphyrin Interaction with Links to Acyclic β-Sheet Peptide Self-Assembled in an Aqueous Media
• Average Crystal Structure of (Pro-Pro-Gly)_9 at 1.0 A Resolution
• Synthesis of [Hexafluorovalyl^]gramicidin S
• Artificial Membrane Protein Functionalized with Electron Transfer System
• Synthesis of a Catalytic Molten Globule with Flavin Function
• Chiral Assembly of Porphyrins Regulated by Amphiphilic α-Helix Peptides
• Self-Assembling of Porphyrin-Linked Amphiphilic β-Sheet Peptides
• Lipidation of the Collagen Model Peptide to Make Peptide-Surfactant
• Synthesis of [5-Bipyridylalanyl^gramicidin S and Its Complexation with Divalent Metal Ions
• Tandem Enzymatic Resolution Yielding L-α-Aminoalkanedioic Acid ω-Esters
• Self-assembling Cyclic Peptides for Peptide Nanotube Formation
• The NMR Spectroscopic Evaluation of Immobility of a Crowd of Porphyrin Rings Combined with Dendritic Poly(L-lysine)s
• The Conformation of de Novo Designed Amphiphilic Peptides with Six or Nine _L-2-(2,2,2-Trifluoroethyl) glycines as the Hydrophobic Amino Acid
• Fluorescence Energy Transfer in Dendritic Poly(L-lysine)s Combining Thirty-two Free Base-and Zinc(II)-porphyrins in Scramble Fashion
• De Novo Design of Hemoprotein Model with Peroxidase Activity toward Lipophilic Peroxide
• Formation of the Amphiphilic β-Structure of a Peptide-Porphyrin Conjugate
• Synthesis of Cyclic Tetrapeptides Containing Non-natural Imino Acids
• High Throughput Screening System for Histone Methyltransferase Inhibitors
• Host-Guest Study of Collagen Model Peptide with Pipecolic Acid
• Helical Propensity of Pipecolic Acid in Collagen Model Peptides
• Synthesis and Characterization of Collagen Model Peptides with A Pyrene Group at the Amino-Terminal
• Facile Preparation of Hydroxyproline Derivatives and Separation of Stereoisomers
• Synthesis and Characterization of Antimicrobial Peptide Surfactants with Dendritic Lysine Groups
• Bicyclic Tetrapeptides with Disulfide as Histone Deacetylase Inhibitors
• Evaluation of Functional Groups as HDAC Inhibitors on Monopeptide Derivatives
• Self-assembling Cyclic Hexapeptides for Peptide Nanotube Formation
• Efficient Production of Monoclonal Antibodies Specific to Aimed Epitope Sequences by a B Cell Targeting Technique
• Cyclization Test and Optimization of Cyclization Condition for Cyclic Tetrapeptides with Various Configurations
• Cyclic Tetrapeptides containing N-Isopropylglycine as Histone Deacetylase Inhibitors
• Synthesis and Activity of Cyl-1 Analogs Having Hydroxamic Acid at Side Chain
• Histone Deacetylase Inhibitors Based on Trapoxin B
• Conformational Analysis of Non-Natural LDLD-Type Cyl-1 Analog with High Activity
• Amyloid Fibril Formation of a Simple Decapeptide in a Micellar Environment
• Histone deacetylase inhibitors block nuclear factor-κB-dependent transcription by interfering with RNA polymerase II recruitment
• Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines
• Sequence Dependence in Cyclization Reaction for Cyclic Tetrapeptides Different in Configurations

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