Tandem Enzymatic Resolution Yielding L-α-Aminoalkanedioic Acid ω-Esters
スポンサーリンク
概要
- 論文の詳細を見る
The tandem action of serine protease (α-chymotrypsin or subtilisin BPN') and Aspergillus genus aminoacylase on racemic N-acetyl-α-aminoalkanedioic acid α, ω-diester produced L-α-aminoalkanedioic acid ω-ester in good yield and high optical purity. L-α-Aminosuberic acid ω-ester thus obtained was conveniently introduced into an oxytocin analog, [Asu^<1,6>]oxytocin, by the solid-phase-synthesis and cyclization-cleavage method with oxime resin.
- 公益社団法人日本薬学会の論文
- 1996-01-15
著者
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NISHINO Norikazu
Department of Applied Chemistry, Faculty of Engineering, Kyushu Institute of Technology
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ARAI Toru
Department of Applied Chemistry, Faculty of Engineering, Kyushu Institute of Technology
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Arai Toru
Research Laboratory Oki Electric Industry Co. Ltd.
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Nishino Norikazu
Department Of Applied Chemistry Faculty Of Engineering Kyushu Institute Of Technology
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UENO Yukio
Central Research Institute, Asahi Glass Co., Ltd.,
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OHBA Masataka
Central Research Institute, Asahi Glass Co., Ltd.,
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Arai T
Oki Electric Ind. Co. Ltd. Tokyo Jpn
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Ohba Masataka
Central Research Institute Asahi Glass Co. Ltd.
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Ueno Yukio
Central Research Institute Asahi Glass Co. Ltd.
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Nishino Norikazu
Department Of Biological Functions And Engineering Graduate School Of Life Science And Systems Engin
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ARAI Toru
Department of Applied Chemistry, Faculty of Engineering, Kumamoto University
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