Behavior and mitotic cycle of tumor cells with lobated nuclei in the MTK-IV tumor

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The present paper describes the results of some observations on the behavior and mitotic cycle of tumor cells with lobated nuclei in the MTK-IV tumor. The MTK-IV tumor used here was induced by Tanaka and Kanô (Feb. 1954, unpublished) in the course of hepatoma-producing experiments through the application of azo-dyes in a Wistar rat.In the tumor samples taken during 53 to 102 transfer generations the frequency in occurrence of tumor cells with lobated nuclei of similar size was observed. Twenty to thirty percent of tumor cells was characterized by lobated nuclei. The daily observations of the frequency of cells with lobated nuclei showed that they increased during the early part of a transplant generation and decreased towards the latter part. Further, the mitotic rate of tumor cells with lobated nuclei is higher than that of regular mononucleate cells through the early part of a transplant generation.Morphological observations showed that different nuclear lobes of the same cell were synchronous in mitotic procedure, and that the prophasic changes proceeded normally in all of them. After the disappearance of the nuclear membrane, the metaphase plate was formed by the original chromosome grouping in different lobes. The metaphase was highly regular, and the anaphase also normal. The telophase proceeded regularly in its beginning. Later on during telophase, the swelling of telophase nuclei seemed to have influence on the formation of nuclear lobes The formation of lobated nuclei did not deal with the multipolar division at all.It is thus evident that the tumor cells with lobated nuclei of the MTK-IV do not represent degenerating cell types but are recognized as normally occurring stages in the mitotic cycle of tumor cells of this tumor.
日本遺伝学会の論文

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外村晶
北海道大学理学部動物学教室

Behavior and mitotic cycle of tumor cells with lobated nuclei in the MTK-IV tumor

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