シロネズミの腹水肉腫におけるメタクロマジー顆粒に関する研究(予報)
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概要
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Metachromatic substance which is regarded as a polysaccharide ester sulfate of unknown chemical composition has been demonstrated in many ordinary tissue cells, but little has been known on its distribution in the malignant cells. The present paper describes the results of investigations on the metachoromatic granules occurring in the tumor cells of the following five rat ascites tumors, MTK-sarcoma II and III, Hirosaki sarcoma, Takeda sarcoma and Usubuchi sarcoma. The observations were carried out through the supravital staining method with 0.02 per cent alcoholic solutions of toluidine blue, methylene blue and nile blue sulphate. By the application of supravital technique with toluidine blue or methylene blue, the majority of the tumor cells showed in the cytoplasm reddish granules which arranged in a characteristic rosette form. They were found distributed at one side of the kidney-shaped nucleus in the cytoplasm. Metachromatic granules are very remarkable in occurrence in tumor cells of MTK-sarcoma II and III, while they are less in number in Hirosaki sarcoma cells than in the above tumors. They are generally invisible in Takeda sarcoma cells. In Usubuchi sarcoma cells the metachromatic granules were found scattered in the cytoplasm without showing a rosette arrangement. In every cell, the general morphological features of the metachromatic granules are similar to those of the granules demonstrated by neutral red. Throughout a transplant generation of MTK-sarcoma II, the daily frequency of the cells having metachromatic granules was studied. On the 3rd to 6th day after transplantation of the tumor, they showed a high frequency in appearance. Evidence presented suggests that the cytoplasmic granules showing metachromasy may occur in association with metabolic activity of the tumor cells.
- 社団法人日本動物学会の論文
- 1955-05-15
著者
関連論文
- 皮下に移植したネズミの腹水肉腫, MTK肉腫IIの染色体調査
- シロネズミの腹水肉腫におけるメタクロマジー顆粒に関する研究(予報)
- 子宮癌の数例における染色体研究
- Behavior and mitotic cycle of tumor cells with lobated nuclei in the MTK-IV tumor