Impaired Postnatal Development in C/EBPβ-deficient Mice
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概要
- 論文の詳細を見る
Tail DNA genotyping of fetal and neonatal mice from C/EBPβ heterozygous parents was performed to determine whether the decreased number of surviving C/EBPβ mutants was caused by prenatal or postnatal death. Eighty-four 3-week-old mice born of heterozygous parents had significantly lower numbers of C/EBPβ-deficient offspring than the expected Mendelian ratio (29.8%+/+, 65.5%+/-, 4.76%-/-, p<0.05). The genotypes of 72 fetal mice from intercrossed heterozygotes showed approximately the expected 1:2:1 Mendelian ratio (18.1% +/+, 52.8% +/-, 29.2% -/-, p>0.05). No difference in the proportions by sex could be detected in these perinates. This data indicates that C/EBP β-deficient mice have unknown lethal problems between the embryonic stage and weaning.
- 日本繁殖生物学会の論文
- 2006-10-01
著者
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TANAKA TETSUJI
Department of Obstetrics & Gynecology, Osaka City University Medical School
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Yukawa Kazunori
Department of Physiology, Wakayama Medical University School of Medicine
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AKIRA Shizuo
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University
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Tanaka Tetsuji
Department Of Obstetrics And Gynecology Wakayama Medical University
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BAI Tao
Department of Obstetrics and Gynecology, Wakayama Medical University
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UMESAKI Naohiko
Department of Obstetrics and Gynecology, Wakayama Medical University
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MATSUMOTO Makoto
Department of Host Defence, Research Institute of Microbial Disease, Osaka University
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Yukawa Kazunori
Department Of Physiology Faculty Of Pharmacy Meijo University
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Yukawa Kazunori
Department Of Physiology Wakayama Medical University
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Bai Tao
Department Of Obstetrics And Gynecology Wakayama Medical University
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Akira Shizuo
Department Of Biochemistry Hyogo College Of Medicine
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Umesaki Naohiko
Department Of Obstetrics And Gynecology Wakayama Medical University
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Umesaki Naohiko
Department Of Obstetrics & Gynecology Wakayama Medical University
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Akira Shizuo
Department Of Host Defence Research Institute Of Microbial Disease Osaka University
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Matsumoto Makoto
Department Of Biochemistry Hyogo College Of Medicine
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Matsumoto Makoto
Department Of Host Defence Research Institute Of Microbial Disease Osaka University
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