The Wakayama Epileptic Rat(WER), a New Mutant Exhibiting Tonic-clonic Seizures and Absence-like Seizures
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概要
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A new mutant, the Wakayama epileptic rat (WER), exhibiting both spontaneous absence-like behavior and tonic-clonic convulsions, was identified in a colony of Wistar rats. To determine clear seizure characteristics of this mutant strain, we analyzed the mode of inheritance of the convulsion and observed patterns of electroencephalogram (EEG) during the seizures. F1 progeny were produced between the founder male and normal females of the same colony. Animals were monitored through the inbreeding course to analyze genetic control of epileptic behavior. EEGs were recorded using affected animals in the F3-4 and post F13 generations. After the F2 generation, affected rats spontaneously exhibited both absence-like immobile behavior and tonic-clonic convulsions. The absence-like seizures were characterized by motor arrest and head droop. The tonic-clonic convulsions began with neck and forelimb clonus, wild jumping/running, and opisthotonic posturing, and evolved to tonic, then clonic convulsions. Most convulsion onsets occurred between 25-70 days of age. Mating experiments revealed that 0%(0/18) of the animals in F1, 10%(3/26) in F2, 17%(1/6) in backcross progeny and 86% (100/116) in progeny of crosses between epileptic rats showed tonic-clonic convulsions. Ictal cortical EEGs were characterized by 4-6 (5.1 0.4, mean SD) Hz spike-and-wave complexes in the absence-like seizures and by low-voltage fast waves in the tonic-clonic convulsions. This new mutant rat spontaneously exhibited both absence-like and tonic-clonic seizures. The tonic-clonic seizure was inherited as an autosomal recessive trait with 86% incidence. Thus, the new mutant rat may become a useful model for studying human inherited epilepsies.
- 社団法人 日本実験動物学会の論文
- 2003-01-01
著者
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Yukawa Kazunori
Department of Physiology, Wakayama Medical University School of Medicine
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Maeda Masanobu
Department of Physiology, Wakayama Medical University School of Medicine
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Tsubota Yuji
Department of Physiology, Wakayama Medical University of Medicine
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Maeda Masanobu
Department Of Physiology Wakayama Medical University
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Maeda Masanobu
Department Of Cardiovascular Surgery Aichi Children's Health And Medical Center
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Yukawa Kazunori
Department Of Physiology Faculty Of Pharmacy Meijo University
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MIYASHITA Eizo
Laboratory of Neurophysiology, National Institute for Physiological Sciences
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MIYAJIMA Masayasu
Laboratory Animal Center, Wakayama Medical University
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OWADA-MAKABE Kyoko
Department of Physiology, Wakayama Medical University
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Owada-makabe Kyoko
Department Of Physiology Wakayama Medical University
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Tsubota Yuji
Department Of Fixed Prosthodontics Tsurumi University School Of Dental Medicine
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Tsubota Yuji
Department Of Physiology Wakayama Medical University Of Medicine
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Miyashita Eizo
Laboratory Of Neurophysiology National Institute For Physiological Sciences
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Maeda Masanobu
Department Of Physiology Wakayama Medical University School Of Medicine
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Miyajima Masayasu
Department Of Physiology Wakayama Medical University
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Miyajima Masayasu
Laboratory Animal Center Wakayama Medical University
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Maeda Masanobu
Department Of Cardiovascular Surgery
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Yukawa Kazunori
Department Of Physiology Wakayama Medical University School Of Medicine
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