Hazelnut Oil Administration Reduces Aortic Cholesterol Accumulation and Lipid Peroxides in the Plasma, Liver, and Aorta of Rabbits Fed a High-cholesterol Diet
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概要
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Hazelnut oil (HO) is rich in monounsaturated fatty acids and antioxidants. We wanted to investigate the effect of HO on lipid levels and prooxidant–antioxidant status in rabbits fed a high-cholesterol (HC) diet. An HC diet caused significant increases in lipids and lipid peroxide levels in the plasma, liver, and aorta together with histopathological atherosclerotic changes in the aorta. Glutathione levels, glutathione peroxidase, and glutathione transferase activities decreased significantly, but superoxide dismutase activity and vitamin E and C levels remained unchanged in the livers of rabbits following HC diet. HO supplementation reduced plasma, liver, and aorta lipid peroxide levels and aorta cholesterol levels together with amelioration in atherosclerotic lesions in the aortas of rabbits fed an HC diet, without any decreasing effect on cholesterol levels in the plasma or liver. HO did not alter the antioxidant system in the liver in the HC group. Our findings indicate that HO reduced oxidative stress and cholesterol accumulation in the aortas of rabbits fed an HC diet.
- 社団法人 日本農芸化学会の論文
- 2004-10-23
著者
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Cevikbas Ugur
Department Of Pathology Istanbul Faculty Of Medicine Istanbul University
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Uysal Mujdat
Department Of Biochemistry Istanbul Faculty Of Medicine University Of Istanbul
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Balkan Jale
Department Of Biochemistry Istanbul Faculty Of Medicine University Of Istanbul
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Kucuk Mutlu
The Experimental And Medical Research Center University Of Istanbul
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Kanbagli Oznur
Department Of Biochemistry Istanbul Faculty Of Medicine University Of Istanbul
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Hatipoglu Aydan
Department Of Biochemistry Istanbul Faculty Of Medicine University Of Istanbul
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Aykac-toker Gulcin
Department Of Biochemistry Istanbul Faculty Of Medicine University Of Istanbul
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BERKKAN Hakan
Department of Biochemistry, Pharmacy Faculty, University of Istanbul
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Berkkan Hakan
Department Of Biochemistry Pharmacy Faculty University Of Istanbul
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