Hepatic Mitochondrial Prooxidant and Antioxidant Status in Ethanol Induced Liver Injury in Rats
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概要
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In this study, prooxidant and antioxidant status in liver homogenates and their mitochondrial fractions were investigated in both chronic and chronic plus acute ethanol-treated rats. Increases in serum transaminase activities, as well as increases in total lipid, triglyceride, malondialdehyde (MDA) and diene conjugate (DC) levels and decreases in glutathione (GSH), vitamin E and vitamin C levels, have been observed in liver homogenates following chronic ethanol treatment (20% ethanol, v/v as drinking water for 3 months), but CuZn-superoxide dismutase (CuZnSOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities remained unchanged in postmitochondrial fractions. When an acute dose of ethanol (5 g/kg, i.p.) was given rats which had received ethanol chronically, serum transaminase activities and hepatic lipid and MDA and DC levels increased further, but GSH levels and antioxidant enzymes decreased more compared to the chronic ethanol-treated rats. There were no significant differences in the levels of MDA, DC and protein carbonyl and the activities of GSH-Px and GST in the hepatic mitochondrial fraction of rats following both chronic and chronic plus acute treatments. Mn-superoxide dismutase (MnSOD) activities increased in both groups, but mitochondrial GSH levels decreased only after chronic plus acute treatment. Therefore, we suggest that the increase in MnSOD activity may play an important role in the regulation of mitochondrial susceptibility against ethanol-induced oxidative stress.
- 公益社団法人日本薬学会の論文
- 2002-11-01
著者
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Uysal Miijdat
Department Of Biochemistry Istanbul Medical Faculty University Of Istanbul
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KANBAGLI Oznur
Department of Biochemistry, Istanbul Medical Faculty, University of Istanbul
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Balkan Jale
Department Of Biochemistry Istanbul Faculty Of Medicine University Of Istanbul
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Balkan Jale
Department Of Biochemistry Istanbul Medical Faculty University Of Istanbul
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Kanbagli Oznur
Department Of Biochemistry Istanbul Faculty Of Medicine University Of Istanbul
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Kanbagli Oznur
Department Of Biochemistry Istanbul Medical Faculty University Of Istanbul
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Aykac-toker Gulcin
Department Of Biochemistry Istanbul Faculty Of Medicine University Of Istanbul
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AYKAC-TOKER Giilcin
Department of Biochemistry, Istanbul Medical Faculty, University of Istanbul
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Aykac-toker Giilcin
Department Of Biochemistry Istanbul Medical Faculty University Of Istanbul
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