Taurine Treatment Reduces Hepatic Lipids and Oxidative Stress in Chronically Ethanol-Treated Rats
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概要
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In this study, we evaluated whether taurine treatment has a protective effect on the prooxidant-antioxidant state following chronic ethanol treatment in rats. Rats were given water containing 20% ethanol (v/v) as drinking water for 3 months. Chronic ethanol treatment in drinking water resulted in increased oxidative stress in the liver of rats. Taurine treatment was performed by adding 1% taurine (w/v) to the drinking water plus injection (400 mg/kg body weight) intraperitoneally 3 times/week for 28 d after ethanol cessation in chronically ethanoltreatad rats. This treatment starting after ethanol cessation caused a significant decreases in serum transaminase activities and hepatic total lipid, triglyceride, malondialdehyde, and diene conjugate levels and significant increases in hepatic glutathione, vitamin E, and vitamin C levels, but did not alter the activities of superoxide dismutase, glutathione peroxidase, and glutathione transferase in the liver as compared with chronically ethanoltreated rats. Accordingly, we propose that taurine has a restorative effect on ethanol-induced hepatic damage by decreasing oxidative stres.
- 公益社団法人日本薬学会の論文
- 2002-09-01
著者
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Uysal M
Department Of Biochemistry Istanbul Faculty Of Medicine Istanbul University
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Uysal Mujdat
Department Of Biochemistry Istanbul Faculty Of Medicine University Of Istanbul
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BALKAN Jale
Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University
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AYKAC-TOKER Gulcin
Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University
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Balkan J
Department Of Biochemistry Istanbul Faculty Of Medicine Istanbul University
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Balkan Jale
Department Of Biochemistry Istanbul Faculty Of Medicine University Of Istanbul
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Kanbagli O
Univ. Istanbul Istanbul Tur
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Kanbagli Oznur
Department Of Biochemistry Istanbul Faculty Of Medicine University Of Istanbul
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Aykac‐toker G
Department Of Biochemistry Istanbul Faculty Of Medicine Istanbul University
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Aykac-toker Gulcin
Department Of Biochemistry Istanbul Faculty Of Medicine University Of Istanbul
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