Inhibitory Effect of Porphyran, Prepared from Dried "Nori", on Contact Hypersensitivity in Mice
スポンサーリンク
概要
- 論文の詳細を見る
Porphyran is a major component of the red algae, Porphyra tenera and P. yezoensis, which are processed into a sheet type of dried food, “Nori”. Porphyran has been reported to activate murine macrophages by in vitro and i.p. injection studies. The contact hypersensitivity (CHS) reaction in mice is commonly used as a model to evaluate the anti-allergic activity of food and food components. We therefore studied the effect of porphyran on the CHS reaction in Balb/c mice to evaluate anti-allergic activity of porphyran. We found that an oral administration of porphyran (2% in drinking water) suppressed the CHS reaction (ear edema) induced by 2,4,6-trinitrochlorobenzene. We also found that porphyran suppressed the serum level of IgE and the production of interferon-γ (IFN-γ) in the challenged ear lobe. We conclude from these results that the CHS reaction was suppressed by oral porphyran due to the decreased serum level of IgE and the production of IFN-γ in the challenged ear lobe.
- 社団法人 日本農芸化学会の論文
- 2005-10-23
著者
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Murata Masakazu
National Research Institute Of Fisheries Science Fisheries Research Agency
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ISHIHARA Kenji
National Research Institute of Fisheries Science
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MATSUSHIMA Ryoji
National Research Institute of Fisheries Science
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MURAOKA Toshihiko
Food Science Research Division, Kumamoto Prefectural Fisheries Research Center
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MURAOKA TOSHIHIKO
Kumamoto Prefectural Fisheries Research Center
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Oyamada Chiaki
Functional Biochemistry Section Marine Biochemistry Division National Research Institute Of Fisherie
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Ishihara Kenji
Functional Biochemistry Section Marine Biochemistry Division National Research Institute Of Fisherie
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Murata Masakazu
National Res. Inst. Of Fisheries Sci. Fisheries Res. Agency
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Oyamada Chiaki
National Research Institute Of Fisheries Science
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Muraoka Toshihiko
Food Science Research Division Kumamoto Prefectural Fisheries Research Center
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Matsushima Ryoji
National Research Institute Of Fisheries Science Fisheries Research Agency
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