Synthesis of Bifunctional L-Lysine Derivatives with Phage-inactivating Effect

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概要

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• A new type of lysine derivative connected with dicarboxylic acid was synthesized. The acid was coupled with ε-benzyloxycarbonyl-lysine ethyl ester (Lys(Z)-OEt) by conventional methods of peptide synthesis. The removal of the Z-group from the protected compounds by hydrogenation gave dihydrochlorides of the final products: succinyl-Lys-OEt, glutaryl-Lys-OEt, adipoyl-Lys-OEt, pimeloyl-Lys-OEt, suberoyl-Lys-OEt, azelaoyl-Lys-OEt and sebacoyl-Lys-OEt. Among the eight products, azelaoyl-Lys-OEt dihydrochloride showed the highest inactivating effect on several phages.

• 社団法人 日本農芸化学会の論文

著者

• Murata Akira

  Laboratory Of Applied Microbiology Department Of Agricultural Chemistry Saga University

• Kondo Michio

  Laboratory of Biochemistry, Faculty of Science 33, Kyushu University

• SHIMIZU Yoshikazu

  Laboratory of Organic Chemistry, Department of Chemistry, Saga University

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• Synthesis of Bifunctional L-Lysine Derivatives with Phage-inactivating Effect

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