Hydroxyl Radical as the Reactive Species in the Inactivation of Phages by Ascorbic Acid(Biological Chemistry)

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概要

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• The oxygen radical species responsible for the inactivation of phages by ascorbic acid was investigated, using four phages of different nucleic acid types. A scavenger for the superoxide anion radical (O_2^-) and scavengers for the hydroxyl radical (OH・)Markedly prevented the inactivation of phages by ascorbic acid. Quenchers for singlet oxygen (^1O_2) slightly prevented the inactivation. Catalase fully prevented the inactivation, whereas superoxide dismutase only partially prevented it. Phages were markedly inactivated in an OH・-generating system, but not in an O_2^--generating system or an ^1O_2-generating system. These results, taken together, indicate that OH・ is the major reactive species and that it is directly responsible for the inactivation of phages by ascorbic acid.

• 社団法人日本農芸化学会の論文
• 1986-06-23

著者

• SUENAGA Hikaru

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Kyushu University

• Suenaga Hikaru

  Laboratory Of Applied Microbiology Department Of Agricultural Chemistry Saga University:(present Off

• Murata A

  Saga Univ. Saga Jpn

• Kato F

  Saga Univ. Saga Jpn

• MURATA Akira

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Saga University

• HIDESHIMA Shigetaka

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Saga University

• TANAKA Yoshihiro

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Saga University

• KATO Fumio

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Saga University

• Hideshima Shigetaka

  Laboratory Of Applied Microbiology Department Of Agricultural Chemistry Saga University

• Kato Fumio

  Laboratory Of Applied Microbiology Department Of Agricultural Chemistry Saga University

• Murata Akira

  Laboratory Of Applied Microbiology Department Of Agricultural Chemistry Saga University

• Tanaka Yoshihiro

  Laboratory Of Applied Microbiology Department Of Agricultural Chemistry Saga University

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• Hydroxyl Radical as the Reactive Species in the Inactivation of Phages by Ascorbic Acid(Biological Chemistry)
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