Synthesis of Higher Homologs of Bifunctional L-Lysine Derivatives with Phage-inactivating Effect

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概要

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• Higher homologs of lysine derivatives consisting of L-lysine and dicarboxylic acids were synthesized. The acids ranged from carbon atoms C11 to C17 and C20 and were coupled with ε-benzyloxycarbonyl- lysine ethyl ester (Lys (Z)-OEt) by conventional methods of peptide synthesis. The removal of the Z-group from the protected compounds by hydrogenation gave the final products as bifunctional agents: undecanedioyl-Lys-OEt, dodecanedioyl-Lys-OEt, tridecanedioyl- Lys-OEt, tetradecanedioyl-Lys-OEt, pentadecanedioyl-Lys-OEt, hexadecanedioyl-Lys-OEt, heptadecanedioyl-Lys-OEt and eicosanedioyl-Lys-OEt. All the products showed a greater inactivating effect on several phages than azelaoyl-Lys-OEt, which showed the highest phageinactivating effect amongthe compoundsreported in our previous paper.

• 社団法人 日本農芸化学会の論文

著者

• Murata Akira

  Laboratory Of Applied Microbiology Department Of Agricultural Chemistry Saga University

• Kondo Michio

  Laboratory of Biochemistry, Faculty of Science 33, Kyushu University

• SAMOTO Masahiko

  Laboratory of Applied Microbiology, Department of Agricultural Chemistry, Saga University

• YADA Yukihiro

  Laboratory of Organic Chemistry, Department of Chemistry, Saga University

• YADA Yukihiro

  Laboratory of Biological Chemistry, Faculty of Agriculture, Saga University

• KONDO Michio

  Laboratory of Organic Chemistry, Department of Chemistry, Saga University

• MIYAZAKI Koujiro

  Laboratory of Organic Chemistry, Department of Chemistry, Saga University

• HORIMOTO Hideaki

  Laboratory of Organic Chemistry, Department of Chemistry, Saga University

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