Isolation and Properties of Ribocitrin
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概要
- 論文の詳細を見る
A dextransucrase inhibitor, ribocitrin, was purified about 580-fold from a culture broth of Streptomyces neyagawaensis MF980-CF1 by combination chromatography. Ribocitrin is a previously unknown type of oligosaccharide composed of ribose. It inhibited the crude preparation of dextransucrase noncompetitively with regard to sucrose and the inhibitory activity (Inh%) was sensitive to pH. It was very stable at alkaline pH values, but gradually lost its inhibitory activity as the acidity increased. It had no antimicrobial activity. It did not inhibit glycoside hydrolases and was not susceptible to the above enzymes. It had a low toxicity. Plaque formation of Streptococcus mutans E49 on a smooth glass surface was diminished by ribocitrin and the colony form of this microorganism on Mitis Salivarius agar was evidently affected by ribocitrin.
- 社団法人 日本農芸化学会の論文
著者
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OKAMI Yoshiro
Institute of Microbial Chemistry
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TAKASHIO Masachika
Institute of Microbial Chemistry
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KURASAWA Shogo
Institute of Microbial Chemistry
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