Mechanisms of 5-Inosinic Acid Accumulation by. Permeability Mutants of Brevibacterium ammoniagenes. II. Sensitivities of a Series of Mutants to Various Drugs
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概要
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A series of mutants of Brevibacterium ammoniagenes selected for increased productivity of 5-inosinic acid (5-IMP) after successive mutational works were analyzed for the level of sensitivity toa variety of drugs. It was found that the series of mutants exhibited variations in sensitivity tovarious drugs such as antibiotics, detergents, dyes and lysozyme. The most notable alterations werefound in a Mn-insensitive mutant, KYI3171, and a guanine auxotrophic mutant, KYI3184, compared to each parent mutant. Furthermore, it was found that increased 5-IMP productivity was always accompanied by increased sensitivity to deoxycholate and lysozyme, and that both the increased level of 5-IMP production and increased degrees of sensitivity to these two drugs in all steps of mutation were not so drastic, but progressive.
- 社団法人 日本農芸化学会の論文
著者
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Teshiba Sadao
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Furuya Akira
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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