Structure of Mildiomycin D

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概要

• 論文の詳細を見る

• A new nucleoside antibiotic, mildiomycin D, was isolated from the culture broth of Streptoverticillium rimofaciens B-98891as a minor component. Themolecular formula of the antibiotic purified by silica gel and ion exchange resin columnchromatographies was determined to be C19H30N8O8• (2H2O) from its physicochemical data. The ultraviolet and infrared spectra were very similar to those ofmildiomycin, a major component. On the basis of 1H and 13C-NMRspectra and acidic hydrolysates of the compound, the chemical structure of the antibiotic was determined as a deoxy compound at the C8, position in mildiomycin. Mildiomycin D showed weak activities against Gram-positive and negative bacteria, phytopathogenic fungi and some yeasts, and its activity against Rhodotorula rubura was about 40% that of mildiomycin.

• 社団法人 日本農芸化学会の論文

著者

• SAWADA HIDEKAZU

  Applied Microbiology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.,

• IWASA Takashi

  Applied Microbiology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• TASHIRO Shigeki

  Research Laboratories, Agricultural Chemicals Division, Takeda Chemical Industries, Ltd.

• SUGITA Norio

  Research Laboratories, Agricultural Chemicals Division, Takeda Chemical Industries, Ltd.

• SAWADA Hidekazu

  Applied Microbiology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

関連論文

• Biosynthetic Pathway of 5-Hydroxymethylcytosine by Streptoverticillium rimofaciens : Biosynthetic Studies on Mildiomycin (III)
• Formation of 5-Hydroxymethylcytosine from Cytidine 5'-Mono-Phosphate by Streptoverticillium rimofaciens : Biosynthetic Studies on Mildiomycin (II)
• Microbial Production of Mildiomycin Analogues by the Addition of Cytosine Analogues : Biosynthetic Studies on Mildiomycin (I)
• Structure of Mildiomycin D

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