[総説］The role of fibrinolytic enzymes in in flammatory process of the upper airway and control of the inflammation by antiplasminic agents

概要

論文の詳細を見る
We reviewed the characteristics and level of fibrinolytic enzymes in extracts of tissue with inflammatory disease and experimental inflammation in upper airway. In addition, we reviewed the changes of fibrinolytic activity in the circulating blood in both humans and experimental animals with acute inflammation. Tissue-type plasminogen activator (t-PA) existed in tissue extract of paranasal mucous membrane (PMM) with chronic sinusitis but urokinase-type plasminogen activator (u-PA) did not. Both t-PA and u-PA, however, existed in tissue extract of antrochoanal polyp (AP). The fibrinolytic activity in the circulating blood increased at the initial stage of human acute tonsillitis and Arthus tonsillitis of rabbits. It was presented that fibrinolytic enzymes in inflammation have an important role on extension, ending and repair at the local inflammatory sites. Furthermore, it was suggested that the suppression of the elevated activity of fibrinolytic enzyme might control the process of inflammation at the initial stage of acute inflammation.
琉球医学会の論文