[原著］圧迫による脳障害に関する基礎的研究 : 長期圧迫による脳萎縮の形成過程について
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概要
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The effects of long-standing brain compression were investigated in 26 adult cats. Brain compression was produced by inserting 12 steel balls ( 5mm in diameter,at 10 minute intervals) into extradural space through a small bur hole in the left temporal bone. The animals were divided into six groups according to the compression period ( 1 hr, 6 hrs, 2 days, 7 days, 1 month and 6 months) . in 10 cats of the 1 hr and 6hr group, mean arterial blood pressure and intracranial pressure (ICP) were monitored buring brain compression. Maximum distance of midline shift (MS) and hemispheric area ratio (HAR), an index of the volume of the compressed hemisphere, were calculated and histological evaluation was made in detail. ICP progressively increased up to 30mmHg during ball insertion, but it returned to normal level within6 hours. HAR showed marked reduction in the land 6 month groups. Histologically, chromatolysis, degenaration of neurons and infiltration of microglia were found in the compressed cortex in the 2 day to 6 month groups. Gliosis and destruction of cortical architecture were found in the 1 and 6 mouth groups. These data show that intracranial mass causes prograssive atrophy of the brain tissue. Chromatolysis seems to be a major finding in the brain sustaining longstanding compression and it followed by severe degeneration of neurons and destruction of cortical architecture. Brain atrophy become apparent within 1 month of compression. These findings suggest that brain compression by intracranial mass must be removed within 1 month in order to avoid further brain tissue damage.
- 琉球医学会の論文
- 1991-00-00
琉球医学会 | 論文
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