頻尿,残尿感などに対する塩酸テロジリンの臨床効果

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頻尿,残尿感を訴える神経性頻尿患者など44例に塩酸テロジリン1日24 mgを4週間経口投与した.1)頻尿,残尿感は約45～50%の症例で改善し,うち神経性頻尿患者では約55～65%の改善率であった.2)排尿回数は投与1週後より有意に減少し,4週後には2.2回減少した.3)最終全般改善度判定の結果61.4%の症例に効果を認め,特に神経性頻尿患者では76.7%と高い有効率であった.4)副作用は軽度の排尿困難が1例認められたのみで,臨床検査値の異常変動もなく,概括安全度判定による副作用発現率は2.3%であった.5)全般有用度判定では61.4%の症例に有用性を認めたThe clinical effects of terodiline hydrochloride were evaluated in forty-four patients with urinary frequency and/or sense of residual urine. After a four-week treatment with 24 mg terodiline hydrochloride once daily, subjective symptoms were improved and micturition frequency was decreased significantly. Slight dysuria was reported as a side effect only in one patient. Terodiline hydrochloride is considered to be superiorly effective and safe for the treatment of urinary frequency and sense of residual urine.