Studies on Human Papillomavirus in Urogenital Lesions
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概要
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In urogenital lesions, human papillomavirus (HPV) has been known as the cause of condyloma acuminatum, which has long been considered one of the most commonly diagnosed sex-ually transmitted diseases (STD). HPV has received much attention clinically because HPV has also been detected at a high rate in genital cancers, such as penile cancer and uterine cervical cancer. Accordingly, since it has been shown that HPV is related to the occurrence of not only condyloma acuminatum but also genital cancers, the author studied HPV in urogenital lesions. 1) HPV has been detected at quite a high incidence even from genital organs without any abnormal findings. In subjects in their twenties, an age of high sexual activity, the HPV-positive rate was 8.0% (9/113) in males and 5.3% (10/189) in females. After several weeks, follow-up studies were conducted on HPV-positive cases. HPV was detected in one of 17 males and two of nine females, and the HPV DNA was the same type as at the first examination. However, after 3-4 months, all three cases had become negative for HPV DNA. It was thus speculated that HPV disaappears spontaneously. A multistep process must be necessary for HPV to attach to epithelial cells and form tumors. 2) The HPV-positive rate of condyloma acuminatum tissues was 95.0% (19/20) in males, while it was 100% (2/2) in females. All of these cases were positive for HPV types 6/11, and two cases were also positive for HPV 16. Similar high rates of HPV detection were recorded for the smear specimens of condyloma acuminatum lesions : HPV types 6/11 were found in 95.8% (23/24) of males and 100% (7/7) of females'. HPV can thus be detected using only smears of lesions. It is notewor-thy that four male cases of condyloma acuminatum underwent malignant changes after a long time, and HPV 16 was detected in the tissues of all of the resultant penile cancers. 3) HPV was detected in 63.1% (70/111) of untreated penile cancers and there was a clear ten-dency for HPV 16 to be the most prevalent type. HPV 18 was detected in two cases (1.8%), but HPV 33 could not be detected. The HPV DNA in the penile cancer tissues was located in the nuclei of the cancer cells. HPV 16 was also detected in six lymph node metastatic tissues of penile cancer, and the HPV type was the same as the HPV DNA type in the primary cancer. In cases treated with radiation and chemotherapy, the HPV-positive rate was reduced to 16.7% (2/12). 4) One case of condyloma acuminatum of the urinary bladder was positive for HPV 6/11. It is considered a possibility that HPV entered the urinary bladder by the transurethral route and caused the condyloma acuminatum. HPV was not detected in cases of prostate cancer, benign prostatic hyperplasia, bladder cancer or vulvar cancer.
- 1994-02-01
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