Concentrations of Polychlorinated Biphenyls in Blood Collected from Yusho Patients during Medical Check- ups Performed from 2004 to 2007

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特集号油症とPCB及びダイオキシン関連化合物研究報告第22集責任編集者古江増隆The Twenty-second Reports of the Study on Yusho―PCBs and Dioxin-Related Compounds―Guest Editor Masutaka FurueTo elucidate the exposure levels of polychlorinated biphenyls (PCBs) for Yusho patients, we conducted a congener-specific analysis of polychlorinated biphenyls (PCBs) in blood collected from 242, 237, 300, and 96 Yusho patients during medical check-ups performed from 2004 to 2007, respectively, and in samples from 74, 113, 125, and 148 Yusho-suspected persons during those same years, respectively, and compared the individual congener concentrations of PCBs among the groups of Yusho patients, Yusho-suspected persons, and normal controls with the concentrations previously reported. Among the 209 PCB congeners, 8 congeners of mono-ortho PCBs and 56 congeners of non-dioxin-like PCBs were identified in the blood of Yusho patients and Yusho-suspected persons. Among the PCB congeners measured in the present study, hexaCB-153, hexaCB-138, heptaCB-180, and heptaCB-182/heptaCB-187 showed high ratios to total concentrations of 64 PCB congeners detected in the blood of Yusho patients and Yusho-suspected persons from 2004 to 2007, and the profiles of the major congeners were the same as those obtained in normal controls. With respect to the minor congeners of PCBs, several differences were observed among the three groups. The sums of the concentrations of 64 PCB congeners in the blood of Yusho patients from 2004 to 2007 were 645, 760, 667, and 510 ng g-1 lipid for each year, respectively, and the concentrations were 1.5, 1.8, 1.5, and 1.2 times higher than those of normal controls for each year, respectively. Those of the Yusho-suspected persons were approximately 0.8, 1.1, 0.9, and 1.0 times higher than those of normal controls for each year, respectively. The ratios of heptachlorinated biphenyls (heptaCBs) to the total concentrations of 64 PCB congeners in the blood of Yusho patients and Yusho-suspected persons from 2004 to 2007 tended to be slightly higher than those in the normal controls. From the results comparing the concentrations of 64 PCB congeners in the blood between Yusho patients and normal controls, the concentrations of hexaCB-156, hexaCB-157, heptaCB-181, and heptaCB-189 for Yusho patients were 3.4, 3.8, 3.9, and 3.8 times, respectively, 3.9, 4.1, 3.9, and 4.4 times, respectively, 3.6, 3.9, 5.0, and 4.1 times, respectively, and 2.3, 2.5, 2.7, and 2.9 times higher than those of the normal controls for each year from 2004 to 2007, respectively. These results indicated that Yusho patients still have higher concentrations of hexaCB-156, hexaCB-157, heptaCB-181, and heptaCB-189 in their blood than do unaffected people, even though over 35 years have passed since the outbreak of Yusho. These four congeners can therefore be considered to be the most important congeners for evaluating the PCBs exposure of Yusho patients.平成16年から平成19年度に, それぞれ242,237,300 および96名の油症患者およびそれぞれ74,113,125 および148名の未認定者から採取した血液中PCBの異性体濃度を測定し,一般健常人の結果と比較した．油症患者と未認定者の血液中において, PCB 64 異性体を分離・定量した. 油症患者の血液中, hexaCB-153, hexaCB-138, heptaCB-180 およびheptaCB-182/187 は他と比較して高い濃度を示したが, この結果は一般健常人と同じであった. 平成16 年から19年度に受診した油症患者血液中PCB の64異性体総濃度は, それぞれ645,760,667および510 ng g-1 lipid で, その濃度は一般健常人のそれぞれ1.5, 1.8, 1.5 および1.2倍であった．未認定者の場合, 総PCB濃度はほぼ健常人と同レベルであった. PCB総濃度に対する各異性体の割合を比較した結果, 油症患者と未認定者のheptaCBs 濃度は一般健常人より高かった. 油症患者の血液中64PCB 異性体濃度を健常人と比較した場合, hexaCB-156, hexaCB-157, heptaCB-181 およびheptaCB-189 の濃度は，一般健常人のそれぞれ2.3-3.9, 2.5-4.1, 2.7-5.0 および2.9-4.4倍高い値を示した. 以上の結果から. 油症発症から35 年以上が経過した現在も患者の血液中PCB 濃度, 特にhexaCB-156, hexaCB-157, heptaCB-181 およびheptaCB-189 濃度は以前高いレベルにあり, 油症患者のPCB暴露を評価する上で最も重要な異性体であると言える.
福岡医学会,Fukuoka Medical Associationの論文
2009-05-25

Concentrations of Polychlorinated Biphenyls in Blood Collected from Yusho Patients during Medical Check- ups Performed from 2004 to 2007

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