新しい発想に基づく二重濾過血漿交換法の提案(<特集>アフェレシス技術の進歩・普及・教育)

概要

論文の詳細を見る
Double filtration plasmapheresis (DFPP) is one of the modalities of plasmapheresis. DFPP is widely utilized to remove immunoglobulins or low density lipoproteins. Differences in molecular weights of solute to be removed and albumin to be retained make DFPP a more selective procedure than simple plasma exchange. Some modified versions of DFPP have been developed to optimize the relation between the pore size of the second filter and the size of the solute, so that such procedure should maximize the selectivity of removal. However depletion of some coagulation factors cannot be assured, which sometimes causes clinical sequelae. We proposed a novel DFPP system that uses a plasma fractionator for plasma separation instead of an ordinary plasma separator. This system is anticipated not to deplete coagulation factors but to remove IgG, because the filter does not virtually pass coagulation factors. Some modification is warranted from the results of an in vitro study, but we believe the system promising for more selective solute removal, which is the goal of the apheresis therapy.
日本アフェレシス学会の論文
2014-02-28