J025023 シグナル伝達機構を考慮した骨梁リモデリングシミュレーション([J02502]生命体統合シミュレーション(2))

概要

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ignaling molecules expressed by osteocytes, osteoclasts and osteoblasts play important roles in adaptive bone remodeling, however, the mechanism by which these signaling pathways result in the changes of trabecular morphology still remains unclear. In this study, we propose mathematical models for trabecular remodeling considering signaling pathways, and conduct computer simulations using finite element method. Focusing on the movement of remodeling packets on the trabecular surface, we discuss the influence of signaling molecules on the morphological changes of trabeculae based on the trabecular remodeling simulation. First, higher RANKL expression rate results in the higher turnover of the bone remodeling cycle. Second, movement of the remodeling packets, formed by coupling of osteoclasts and osteoblasts, toward unnecessary trabecular bone surface area was observed in which osteoclast precursors sense low OPG concentration.
一般社団法人日本機械学会の論文
2011-09-11