J024012 温熱ストレス下における細胞の死滅率と損傷関数の関連性 : 第2報([J02401]バイオにおける流れと熱・物質移動(1))

概要

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This study investigated the relation between the reaction kinetic model (two-step damage model with two different rate constants) for thermal stress-induced cell death developed by the authors and the damage function for thermal injury of epidermis proposed by Henriques. The cell lethality was related quantitatively to the damage function by three methods, in which different reaction rate constants were used to relate the cell lethality and damage function. The required time to attain the prescribed cell lethality under a constant exposure temperature was plotted together with the required time for the prescribed value of damage function. The result showed that the cell lethality and damage function had the similar tendency. Also, time?dependency of the newly defined damage function for two-step damage model was investigated for each method, and nondimensional time was induced to group the curves of damage function versus time. Finally, the damage function as a function of cell lethality was obtained for each method.
一般社団法人日本機械学会の論文
2011-09-11