P39 超音波刺激で気化するPFC内包リポソームを用いたDDS型がん治療(ポスターセッション)

概要

論文の詳細を見る
Chemotherapy is often complicated by toxic side-effect of the antitumor drugs. To overcome this problem, it is necessary that antitumor drugs are effectively delivered to only tumor tissue. The way is drug delivery system (DDS) using liposome as drug carriers. However, traditional DDS can not achieve full therapeutic effect. This is because controlled drug release in the deep position of the body and carrier dynamics are insufficient. To solve this problem, we used Sendai virus (SeV) envelope glycoprotein on the surface and avidin for optimized in vivo and intracellular kinetics and used ultrasound and liquefied perfluorocarbon for ruptured cancer cell from within. At the first setout, liposomes were modified with avidin as targeted surface of the cancer cell. Furthermore, we coated of the liposome complex with Sev for introduced inclusions into the cytoplasm. In this study, we made the PFC encapsulated avidin modified-fusogenic liposomes (AM-FL), and irradiated it with ultrasound. After that, the transduction efficiency was measured by the flow cytometry in conjunction with the fluorescent material, and the rate of survival cell was measured by the counting chamber.
日本ソノケミストリー学会の論文
2013-10-25