A15 超音波刺激応答性リボソームによる抗がん剤投与システム

概要

論文の詳細を見る
Chemotherapy is often complicated by toxic side-effects of the antitumor drugs. To overcome this problem, it is necessary that antitumor drugs are effectively delivered to only tumor tissue. Drug delivery system (DDS) using liposome as drug carriers has been utilized for this purpose. However, traditional DDS can not achieve full therapeutic effect. This is because controlled drug release in the deep position of the body and carrier dynamics are insufficient. To solve this problem, we used ultrasound for controlled drug release and used DNA aptamer for targeting the carrier for cancer cells. Firstly, liposome was modified with thermosensitive polymer as ultrasound stimulus-responsive carrier. This polymer develops phase transition at a lower critical temperature (LCST) and interacts with liposomal membrane. In this study, we made the Doxorubicin (anti-cancer drug)-loaded thermosensitive liposome (TS-Lipo), and irradiated it with ultrasound. The results indicated that the release of Doxorubicin from TS-Lipo was increased with increasing ultrasound intensity compared to the non-modified liposome. Cell viability of MDA-MB-231 cancer cells exposed to ultrasound and Apt-TSP-Liposome was significantly lower than the control.
日本ソノケミストリー学会の論文
2012-11-09