A05 超音波刺激応答型リポソームを用いたドラッグデリバリーシステムの構築(口頭発表)

概要

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Chemotherapy is often complicated by toxic side-effect of the antitumor drugs. To overcome this problem, it is necessary that antitumor drugs are effectively delivered to only tumor tissue. The way is drug delivery system (DDS) using liposome as drug carriers. However, traditional DDS can not achieve full therapeutic effect. This is because controlled drug release in the deep position of the body and carrier dynamics are insufficient. To solve this problem, we used ultrasound for controlled drug release and used DNA aptamer for collecting carrier in cancer cells. At the first setout, liposome was modified with thermosensitive polymer as ultrasound stimulus-responsive carrier. This polymer develops phase transition at a lower critical temperature (LCST) and interacts with liposomal membrane. In this study, we made the calcein-loaded thermosensitive liposome (TS-Lipo), and irradiated it with ultrasound. After that, the release of calcein from liposome was measured by the fluorescence intensity with a spectrofluorometer. The results indicated that the release of calcein from TS-Lipo was increased with increasing ultrasound intensity compared to the non-modified liposome.
日本ソノケミストリー学会の論文
2010-10-21