P23. Sonodynamic cancer therapy using low-intensity ultrasound with novel porphyrin derivatives(Poster Presentation)
スポンサーリンク
概要
- 論文の詳細を見る
The low-intensity ultrasound with sonosensitizing drug, termed sonodynamic therapy (SDT), is one of the promising approaches for non-invasive and repeatable cancer therapy. Two novel porphyrin derivatives, DCPH-P-Na(I) and DEG, were assessed as a sonosensitizer in SDT using human cancer cell lines in vitro and in vivo mouse genograft model. Both sensitizers indicated the potent sonotoxicity after irradiating low-intensity ultrasound with low or no phototoxicity, and inhibited the tumor growth significantly. Interestingly, the reactive oxygen species generated after ultrasound irradiation depended on the sensitizer used: DCPH-P-Na(I) generated singlet oxygen whereas DEG produced hydroxyl radical, according to the scavenger assay. Although the skin sensitivity was observed in vivo mouse model with ATX-70, a porphyrin derivative that reacts both light and ultrasound, DEG showed no such phenomenon. These results suggest that the novel porphyrin derivatives might be a promising candidate as a sonosensitizing drug in SDT without skin sensitivity.
- 日本ソノケミストリー学会の論文
- 2011-10-15
著者
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Kuroki Masahide
Department Of Biochemistry Cancer Research Institute
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Shibaguchi Hirotomo
Departments of Pharmacology, Nagasaki University School of Medicine
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Tsuru Hirofumi
Department of Biochemistry, Fukuoka University
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Hachimine Ken
Department of Biochemistry, Fukuoka University
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Kuroki Motomu
School of Nursing, Fukuoka University
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Kuroki Masahide
Department of Biochemistry, Fukuoka University
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Shibaguchi Hirotomo
Department of Biochemistry, Fukuoka University
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- P23. Sonodynamic cancer therapy using low-intensity ultrasound with novel porphyrin derivatives(Poster Presentation)