カイコの眼色に関する吉川秀男の研究について(1937〜1950)
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H. Kikkawa's first report on the eye pigmentation in Bombyx was published in 1937. It was one of the pioneering works in the history of biochemical genetics in Japan. Kikkawa's work was apparently influenced by Beadle and Ephrussi's observations on Drosophila. However, it should not be overlooked that the work was rooted deeply in the earlier accumulation of genetical studies on Bombyx in Japan. In the paper, he gave a clue for solving the complex phenomena of so-called maternal inheritance in Bombyx. This finally led to the understanding of the whole process of the formation of eye-pigment. tryptophan→α-oxy-tryptophan→kinurenin→3-hydroxy-kinurenin→pigment In 1941, both Kikkawa and Beadle & Tatum independently published almost the same idea on the possible connection between genes and enzymes. Beadle & Tatum presented the one gene-one enzyme theory after they introduced Neurospora into their study. Kikkawa, however, gradually changed his idea to a more complicated model. It appears that he preferred considering the problems from a physiological point of view rather than analysing them from a genetical one. Furthermore, his co-workers in biochemistry seemed to be interested more in the chemistry of the pigments themselves than the relation between genes and enzymes. This paper describes how Kikkawa's monumental works on the eye-pigmentation of Bombyx were achieved and what his main concern was all through his works.
- 日本科学史学会の論文
- 1980-10-21
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- カイコの眼色に関する吉川秀男の研究について(1937〜1950)
- DNAモデルおよびCentral Dogma受容過程について(I)