An animal model of Parkinson's disease produced by rotenone intraperitoneal injection
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概要
- 論文の詳細を見る
Objective Modeling a stable and reproducible animal model of Parkinson's disease by rotenone intraperitoneal injection for further pathogenesis study of PD. Methods Twenty-seven male Wistar rats were used, which were randomly divided into three groups on average (Rotenone Injection, Vehicle Injection and Normal group). Rats of rotenone injection group (RIG) were administered rotenone (3.0 mg/kg/day) in a specialized vehicle through daily intraperitoneal injection; rats of vehicle injection group (VIG) were administered only special vehicle in the same way, rats of normal group (NG) didn't receive any injection. Checked the changes of its behavior and numbers of SNpc neurons to determine the model successful or not. Results Six rats of RIG developed part of Parkinson's symptoms at different time. All rats of RIG emerged behavioral deficits through rearing behavior testing and square bridge testing, and the mean number of SNpc neurons showed significant reduction. There were no behavioral deficits and changes of the mean number of SNpc neurons in rats of NG and VIG. Conclusion Model of Parkinson's disease by rotenone intraperitoneal injection was successfully established. This form of the rotenone model is stable and easy to reproduce, and may provide a new excellent supporter to related studies.
- 2013-03-30
著者
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Jiang Hong
Department Of Cardiology Renmin Hospital Of Wuhan University
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Sun Xiao
Department of urology, Central Hospital of Taian
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Zhang Zhao-qiang
Department Of Physiology Department Of Basic Medicine Of Taishan Medical College
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Sun Xiao
Department Of Chemistry School Of Pharmacy Fourth Military Medical University
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Sun Xian-chang
Department of Physiology, Department of Basic Medicine of Taishan Medical College
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Chi Xiang-lin
Department of Neurology, Central Hospital Of Wendeng
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Jiang Hong
Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University
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Zhang Zhao-qiang
Department of Physiology, Department of Basic Medicine of Taishan Medical College:Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College
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SUN Xiao
Department of Cardiovascular Surgery, Saitama Medical Center
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- An animal model of Parkinson's disease produced by rotenone intraperitoneal injection
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