Activation of Nuclear Factor Erythroid 2-Related Factor 2 Cytoprotective Signaling by Curcumin Protect Primary Spinal Cord Astrocytes against Oxidative Toxicity
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概要
- 論文の詳細を見る
Oxidative damage plays a critical role in many neurodegenerative diseases. Astrocytes are involved in supporting the survival and protection of neurons against oxidative damage. The dysfunction of antioxidant in astrocytes has been implicated in a variety of neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), spinalmuscularatrophy (SMA). The loss of motor neuron in spinal cord has been attributed to deterioration of astrocytes. The activation of antioxidantive function in astrocytes may serve as a therapeutic strategy for neurodegenerative diseases. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master transcriptional regulator of phase II antioxidantive genes. We report herein that curcumin significantly activates Nrf2 target genes in primary spinal cord astrocytes, decreases the level of intracellular reactive oxygen species (ROS), and attenuates oxidative damage and mitochondrial dysfunction.
著者
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Jiang Hong
Department Of Cardiology Renmin Hospital Of Wuhan University
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Li Chunyan
Department Of Clinical Chemistry And Laboratory Medicine Graduate School Of Medical Sciences Kyushu
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Tian Xinying
Department of Neurology, The Second Hospital of Hebei Medical University
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Guo Yansu
Department of Neurology, The Second Hospital of Hebei Medical University
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Duan Weisong
Department of Neurology, The Second Hospital of Hebei Medical University
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Bu Hui
Department of Neurology, The Second Hospital of Hebei Medical University
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Jiang Hong
Department of Neurology, The Second Hospital of Hebei Medical University
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