水疱性類天疱瘡に対するアフェレシス療法(<特集>皮膚難病とアフェレシス)

概要

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Bullous pemphigoid (BP) is an autoimmune disease producing blisters at the subepidermal area with eosinophillic inflammation. Corticosteroid therapy is the first treatment of choice for patients with BP. Many BP patients are improved by a low to medium dose of steroid, but sometimes refractory to such treatment. However, high-dose systemic corticosteroid or immunosuppressant may cause severe side effects for aged BP patients. Plasmapheresis is also effective to reduce the dose of corticosteroid. It is important to start immediately combination therapy of apheresis in patients who are supposed to be resistant to steroid treatment.
2013-05-31