Serial changes of anti-HCV core titer in patients with chronic hepatitis C treated with peginterferon: a useful marker for outcome contributing to choice of an appropriate therapy
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概要
- 論文の詳細を見る
C型慢性肝炎例でpeginterferon治療(ribavirin併用例を含む)受けた19例を対象とし、治療開始時から経時的にALT、HCV-RNA、anti-HCV core titerを測定した。anti-HCV core titerは、peginterferon・ribavirin併用療法群およびpeginterferon monotherapy療法群とも、SVR例では治療開始後から持続して減少し、治療終了時には減少率は50%に達し、治療終了後はさらに減少を示した。一方non SVR例では、治療開始後も減少傾向は明らかではなく、治療終了後は逆に増加を示した。またSVR例13例中12例がEVRであったことから、EVRで治療中anti-HCV core titerが持続減少を示す場合には、peginterferon・ribavirin併用療法例、peginterferon monotherapy療法例とも治療期間の短縮を考慮することが可能と考えられる。このことはリスク背景を有するC型慢性肝炎例に対して、不要な継続治療を避けより適切なpeginterferonの治療法および治療期間の選択に貢献するものである。
著者
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Nakakarumai Chihoko
Iwate Seiwa Hospital
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Isobe Naoko
Health Administration Center, Iwate Medical University
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Ishikawa Kazuyoshi
Faculty Of Nursing Iwate Prefectual University
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Ishikawa Kazuyoshi
岩手県立大学 看護学部
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Ishikawa Kazuyoshi
岩手医科大学 第1内科
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Isobe Naoko
Health Administration Center Iwate Medical University
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Nitatori Tohru
Faculty Of Nursing Iwate Prefectual University
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