紅花の薬理学的研究(第2報) : 抗炎症作用

概要

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The crude drug "kouka," prepared from the flower petals of Carthamus tinctorius, has been used for the treatment of women's diseases in Oriental medicine. We have recently examined the pharmacological properties of C. tinctorius, and found that it has an analgesic effect, inhibitory effect of spontaneous motor activity, sedative effect and antiinflammatory effect. In the present work, we investigated the preventive action of C. tinctorius on acute and chronic inflammations. A C. tinctorius extract inhibited the hind-paw edema induced by various acute phlagists (carrageenin, histamine, serotonin, bradykinin, prostaglandin E_1) and the vascular permeability increase induced by acetic acid, indicating that it elicits the antiinflammatory activity at the exudative stage of inflammation. The C. tinctorius extract affected neither the proliferation of granulation tissue when tested by the cotton pellet method nor the development of adjuvant arthritis in rats, demonstrating that C. tinctorius extract might not be effective against the chronic inflammation. Furthermore, the C. tinctorius extract inhibited the carrageenin-induced hind-paw edema in sham-operated mice as well as in adrenalectomized mice, suggesting that the antiinflammatory action of the C. tinctorius extract might not be elicited via the adrenal glands.
日本生薬学会の論文
1991-12-20